{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T13:59:24Z","timestamp":1784296764910,"version":"3.55.0"},"reference-count":175,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T00:00:00Z","timestamp":1751760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32471081"],"award-info":[{"award-number":["32471081"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61806210"],"award-info":[{"award-number":["61806210"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82330043"],"award-info":[{"award-number":["82330043"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017596","name":"Natural Science Basic Research Program of Shaanxi Province","doi-asserted-by":"publisher","award":["2024JC\u2010YBQN\u20100209"],"award-info":[{"award-number":["2024JC\u2010YBQN\u20100209"]}],"id":[{"id":"10.13039\/501100017596","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Auditory verbal hallucinations (AVH) are prominent positive symptoms of schizophrenia that frequently prove resistant to conventional antipsychotic treatments. Low\u2010frequency repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising intervention for AVH; however, the underlying neurobiological mechanisms mediating its efficacy remain incompletely understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, schizophrenia patients with AVH were randomly assigned to either an active stimulation group or a sham control group. The active stimulation group received 1\u2009Hz rTMS targeting the left temporoparietal junction (TPJ), while the sham group underwent an identical procedure without actual stimulation. Structural MRI scans were conducted before and after treatment to evaluate changes in gray matter volume (GMV). Further analyses examined associations between GMV changes and both gene expression profiles and neurotransmitter receptor densities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Active rTMS stimulation resulted in a significant reduction in AVH symptoms and was associated with increased GMV in specific cortical regions related to sensory and cognitive processing. These structural changes correlated with gene sets enriched in neuroplasticity\u2010related pathways, such as cell morphogenesis, chromatin remodeling, and vesicle cytoskeletal trafficking. Notable changes were also observed in neurotransmitter receptor densities, particularly for serotonin (5HT1a), dopamine (D1), and glutamate (mGluR5) receptors. Multiple linear regression analysis identified specific hub gene expressions, such as ANK1, and patterns of neurotransmitter density, especially mGluR5, as significant predictors of GMV changes following rTMS stimulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Low\u2010frequency rTMS induced GMV changes, coupled with alterations in gene expression and neurotransmitter receptor densities, contribute to symptom alleviation in schizophrenia patients with AVH. These findings support rTMS as a promising intervention for targeting the neurobiological substrates underlying AVH in schizophrenia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acps.70014","type":"journal-article","created":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T18:39:59Z","timestamp":1751827199000},"page":"372-392","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Transcriptomic and Neurotransmitter Insights Into Gray Matter Volume Changes From 1\u2009Hz <scp>rTMS<\/scp> in Treating Schizophrenia With Auditory Verbal Hallucinations"],"prefix":"10.1111","volume":"152","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9787-8244","authenticated-orcid":false,"given":"Yuanjun","family":"Xie","sequence":"first","affiliation":[{"name":"Military Medical Psychology School, Fourth Military Medical University  Xi'an China"},{"name":"Department of Radiology Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxi","family":"Li","sequence":"additional","affiliation":[{"name":"Military Medical Psychology School, Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muzhen","family":"Guan","sequence":"additional","affiliation":[{"name":"Deparment of Mental Health Xi'an Medical College  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Military Medical Psychology School, Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaozong","family":"Ma","sequence":"additional","affiliation":[{"name":"Military Medical Psychology School, Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Wang","sequence":"additional","affiliation":[{"name":"Military Medical Psychology School, Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Li","sequence":"additional","affiliation":[{"name":"Military Medical Psychology School, Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijun","family":"Li","sequence":"additional","affiliation":[{"name":"Military Medical Psychology School, Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaning","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Fang","sequence":"additional","affiliation":[{"name":"Military Medical Psychology School, Fourth Military Medical University  Xi'an China"},{"name":"Innovation Research Institute, Xijing Hospital, Fourth Military Medical University  Xi'an China"},{"name":"Military Medical Innovation Center Fourth Military Medical University  Xi'an China"},{"name":"Shaanxi Provincial Key Laboratory of Bioelectromagnetic Detection and Intelligent Perception  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm14040391"},{"issue":"9","key":"e_1_2_11_3_1","first-page":"638","article-title":"Schizophrenia: Overview and Treatment Options","volume":"39","author":"Patel K. R.","year":"2014","journal-title":"P & T: A Peer\u2010Reviewed Journal for Formulary Management"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12531"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbw078"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbu005"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbaa103"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.151.12.1744"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2016.01.2038"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2019.04.051"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci3020642"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.09.038"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.01.016"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406\u2010023\u201001624\u20108"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.06.019"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2009.12.011"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2017.04.017"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.722894"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.10.006"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2016.01.006"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064\u2010018\u20102695\u20104"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2125\u201011.2011"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2012.11.010"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3237"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2013.04.005"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2007.08.018"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221\u2010008\u20101356\u20102"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1139\/O10\u2010138"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2010.12.007"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276\u2010018\u20100025\u20101"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2020.528396"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crneur.2022.100033"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1109\/ACCESS.2020.3033029"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.4501"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20184625"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2014.09.012"},{"issue":"11","key":"e_1_2_11_37_1","first-page":"96","article-title":"Releasing the Cortical Brake by Non\u2010Invasive Electromagnetic Stimulation? rTMS Induces LTD of GABAergic Neurotransmission","volume":"10","author":"Lenz M.","year":"2016","journal-title":"Frontiers in Neural Circuits"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2019.06.028"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00457"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2019.3360"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbq135"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2016.05.035"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201017051\u20105"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsgos.2021.10.002"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11405"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2008004117"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201021943\u20105"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291722003750"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291720003876"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.117526"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhac211"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010022\u201001186\u20103"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44220\u2010023\u201000111\u20102"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14690"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2024.05.072"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213\u2010023\u201006323\u20109"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbad047"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2023.1071769"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010024\u201003106\u20104"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.1.49"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.03.041"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.3758\/BF03193146"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/13.2.261"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2015.02.001"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhl183"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2012.114"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhx179"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.01.011"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.07.034"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201009234\u20106"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1131"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059\u2010019\u20101758\u20104"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1186\/1752\u20100509\u20108\u2010S4\u2010S11"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2014.06.005"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2012.169"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2017.124"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010022\u201002253\u2010w"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adk6063"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1159\/000502148"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.575538"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.26614"},{"issue":"12","key":"e_1_2_11_82_1","first-page":"7657","article-title":"Neural Mechanisms Underlying Visual and Auditory Processing Impairments in Schizophrenia: Insight Into the Etiology and Implications for Tailoring Preventive and Therapeutic Interventions","volume":"12","author":"Zhuo C.","year":"2020","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2021.108030"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.831714"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2021.03.008"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep22959"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3862\u201009.2010"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2011.12.016"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2010.03.019"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2011.07.013"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2013.04.005"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.4103\/ajns.AJNS_505_20"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2019.101881"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291723002222"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17204"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2020.08.058"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2014.09.008"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2012.0009"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0b013e31820512d4"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2021.09.006"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010021\u201001397\u20103"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1177\/00048674211016043"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a008151"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2013.00707"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.07.011"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2020.100973"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301544"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00874"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep16873"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311\u2010019\u201000771\u2010y"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756\u20106606\u20107\u201011"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20110153"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.22427"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/3468795"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.711446"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.933772"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0139892"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12195\u2010016\u20100439\u20106"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1844"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064\u2010020\u201003161\u20105"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1106377109"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21237"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010021\u201000366\u20106"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010cellbio\u2010100616\u2010060739"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1021\/sb400128g"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2016.08.003"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033\u2010007\u20109159\u20102"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1450"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2011.09.007"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2013.05.002"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010017\u20102511\u20103"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:MCBI.0000041856.92497.0c"},{"key":"e_1_2_11_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2009.09.005"},{"key":"e_1_2_11_134_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010017\u20100418\u2010y"},{"key":"e_1_2_11_135_1","doi-asserted-by":"publisher","DOI":"10.4161\/cam.21672"},{"key":"e_1_2_11_136_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.147934"},{"key":"e_1_2_11_137_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e17\u201008\u20100488"},{"key":"e_1_2_11_138_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2017.2618"},{"key":"e_1_2_11_139_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2863\u201020.2021"},{"key":"e_1_2_11_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2018.12.003"},{"key":"e_1_2_11_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41594\u2010022\u201000792\u2010w"},{"key":"e_1_2_11_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2021.01.002"},{"key":"e_1_2_11_143_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21228460"},{"key":"e_1_2_11_144_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abd4413"},{"key":"e_1_2_11_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2019.11.007"},{"key":"e_1_2_11_146_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyaa017"},{"key":"e_1_2_11_147_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.13002"},{"key":"e_1_2_11_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2011.05.002"},{"key":"e_1_2_11_149_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2979\u201020.2021"},{"key":"e_1_2_11_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2013.01.011"},{"key":"e_1_2_11_151_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881113482531"},{"key":"e_1_2_11_152_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2018.00051"},{"key":"e_1_2_11_153_1","doi-asserted-by":"publisher","DOI":"10.2174\/2211556009666200401150756"},{"key":"e_1_2_11_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2010.09.002"},{"key":"e_1_2_11_155_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1471"},{"key":"e_1_2_11_156_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010017\u20100071\u20109"},{"key":"e_1_2_11_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.04.033"},{"key":"e_1_2_11_158_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg268"},{"key":"e_1_2_11_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.08.026"},{"key":"e_1_2_11_160_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5366\u201008.2009"},{"key":"e_1_2_11_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2015.08.003"},{"key":"e_1_2_11_162_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0409\u201016.2016"},{"key":"e_1_2_11_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2021.108758"},{"key":"e_1_2_11_164_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3451\u201013.2014"},{"key":"e_1_2_11_165_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582\u20104934.2009.00943.x"},{"key":"e_1_2_11_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2020.04.023"},{"key":"e_1_2_11_167_1","doi-asserted-by":"publisher","DOI":"10.1110\/ps.03554604"},{"key":"e_1_2_11_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crstbi.2021.10.001"},{"key":"e_1_2_11_169_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/12.6.625"},{"issue":"11","key":"e_1_2_11_170_1","first-page":"199","article-title":"Translational Concepts of mGluR5 in Synaptic Diseases of the Brain","volume":"3","author":"Piers T. M.","year":"2012","journal-title":"Frontiers in Pharmacology"},{"key":"e_1_2_11_171_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.301366"},{"key":"e_1_2_11_172_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.30"},{"key":"e_1_2_11_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2012.12.005"},{"key":"e_1_2_11_174_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010015\u20101411\u20106"},{"key":"e_1_2_11_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2023.110735"},{"key":"e_1_2_11_176_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20210989"}],"container-title":["Acta Psychiatrica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acps.70014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:30:30Z","timestamp":1759365030000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acps.70014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,6]]},"references-count":175,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/acps.70014"],"URL":"https:\/\/doi.org\/10.1111\/acps.70014","archive":["Portico"],"relation":{},"ISSN":["0001-690X","1600-0447"],"issn-type":[{"value":"0001-690X","type":"print"},{"value":"1600-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,6]]},"assertion":[{"value":"2025-02-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}