{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:41:55Z","timestamp":1787240515840,"version":"build-2736575974"},"reference-count":5,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/08507\u20103"],"award-info":[{"award-number":["2019\/08507\u20103"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2014\/50873\u20103"],"award-info":[{"award-number":["2014\/50873\u20103"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["465412\/2014\u20109"],"award-info":[{"award-number":["465412\/2014\u20109"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["FAPESP 14\/50873\u20103"],"award-info":[{"award-number":["FAPESP 14\/50873\u20103"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MH113230"],"award-info":[{"award-number":["MH113230"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016220","name":"Georgia Clinical and Translational Science Alliance","doi-asserted-by":"publisher","award":["UL1TR002548"],"award-info":[{"award-number":["UL1TR002548"]}],"id":[{"id":"10.13039\/100016220","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031235","name":"Instituto Nacional de Biomarcadores em Neuropsiquiatria","doi-asserted-by":"publisher","award":["CNPq 465412\/2014\u20109"],"award-info":[{"award-number":["CNPq 465412\/2014\u20109"]}],"id":[{"id":"10.13039\/100031235","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031235","name":"Instituto Nacional de Biomarcadores em Neuropsiquiatria","doi-asserted-by":"publisher","award":["FAPESP 14\/50873\u20103"],"award-info":[{"award-number":["FAPESP 14\/50873\u20103"]}],"id":[{"id":"10.13039\/100031235","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To replicate a previous study addressing differences and similarities of older adults with bipolar disorder (OABD) treated with lithium as compared to those treated with other drugs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cross\u2010sectional analysis of a harmonized dataset of the GAGE\u2010BD Project, with over 2 thousand participants enrolled from two recruitment waves, with worldwide representation. Participants were allocated in two treatment groups according to the availability of information about current lithium use (Lithium, n = 754; Non\u2010lithium, n = 1,161). We used linear regression, linear mixed and generalized linear mixed models\u2009to examine the associations between treatment groups and other variables, with emphasis on the distribution of socio\u2010demographical and clinical variables, controlling for age, gender, and study site.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found statistical associations between lithium use and higher education level, as well as with bipolar\u20101 subtype, and a negative association with comorbid anxiety disorder. OABD patients treated with lithium had lower scores on depression rating scales, and better overall global cognitive and functional state. Lithium users also reported having fewer cardiovascular comorbidities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We found several potentially relevant differences in the clinical profile of OABD treated with lithium; nonetheless, the interpretation of the present results must take into account the methodological limitations inherent to the cross\u2010sectional approach and data harmonization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.70016","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T03:09:00Z","timestamp":1752203340000},"page":"393-396","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Demographic and Clinical Characteristics of Lithium\u2010Treated Older Adults With Bipolar Disorder: A Replication Study From the Global Aging and Geriatric Experiments in Bipolar Disorder (\n                    <scp>GAGE<\/scp>\n                    \u2010\n                    <scp>BD<\/scp>\n                    ) Project"],"prefix":"10.1111","volume":"152","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6962-5899","authenticated-orcid":false,"given":"Orestes V.","family":"Forlenza","sequence":"first","affiliation":[{"name":"Laboratory of Neuroscience (LIM\u201027), Department and Institute of Psychiatry University of S\u00e3o Paulo, Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo, HCFMUSP  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4207-5655","authenticated-orcid":false,"given":"Ni","family":"Xu","sequence":"additional","affiliation":[{"name":"Peking University Sixth Hospital and National Clinical Research Center for Mental Disorders  Beijing China"},{"name":"Peking University Institute of Mental Health and NHC Key Laboratory of Mental Health  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6076-1894","authenticated-orcid":false,"given":"Peijun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Geriatric Psychiatry Division, Geriatric Research, Education and Clinical Center (GRECC) Case Western Reserve University School of Medicine, VA Northeast Ohio Healthcare System  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3908-9124","authenticated-orcid":false,"given":"Soham","family":"Rej","sequence":"additional","affiliation":[{"name":"Lady Davis Institute\/Jewish General Hospital, McGill University  Montreal Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9216-988X","authenticated-orcid":false,"given":"Ariel G.","family":"Gildengers","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0281-8458","authenticated-orcid":false,"given":"Tomas","family":"Hajek","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Dalhousie University  Halifax Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3073-668X","authenticated-orcid":false,"given":"Martha","family":"Sajatovic","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Case Western Reserve University School of Medicine University Hospitals Cleveland Medical Center  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the GAGE\u2010BD initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12795"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.13474"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.6057"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2017.15050657"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102231"}],"container-title":["Acta Psychiatrica 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