{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:43:05Z","timestamp":1787013785376,"version":"build-2736575974"},"reference-count":64,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T00:00:00Z","timestamp":1756598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["514201724"],"award-info":[{"award-number":["514201724"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Bipolar disorder (BD) is a severe mental disorder characterized by extreme mood swings, often accompanied by metabolic comorbidities, such as cardiovascular disease, which increase mortality and reduce quality of life. Both metabolic dysfunctions and BD are associated with cognitive dysfunction. Body mass index (BMI) is closely linked to metabolic health and cognitive performance. This study examined the link between BMI and cognitive function in individuals with BD and how genetic factors, namely polygenic risk scores (PRS) for BD and BMI, might influence this link.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Genetic (PRS scores) and phenotypic data (sociodemographic factors, clinical symptoms and cognitive function) of 341 adult patients with BD diagnosis from the PsyCourse Study, a large, multi\u2010site, and naturalistic longitudinal study, were utilized for this study. First, we performed univariate and multivariate regression analyses to investigate associations between BMI and cognitive performance. Second, moderation analyses were conducted to examine the potential moderator effects of BD\u2010PRS or BMI\u2010PRS in the relationship between BMI and different cognitive outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>BMI was associated with processing speed (TMT\u2010A) and executive function (TMT\u2010B), with individuals with higher BMI showing poorer performance. Moderation analyses revealed that the effect of BMI on cognition was moderated by BD\u2010PRS only regarding the processing speed. BMI\u2010PRS did not moderate the association between BMI and cognitive variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings indicate that the relationship between BMI and cognitive impairment in BD is partially moderated by BD genetic liability but not by BMI genetic load.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.70028","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T05:51:07Z","timestamp":1756705867000},"page":"451-461","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Unravelling the Link Between Body Mass Index and Cognitive Performance in Individuals With Bipolar Disorder and Exploration of\n                    <scp>PRS<\/scp>\n                    Moderation Effect: Findings From the\n                    <scp>PsyCourse<\/scp>\n                    Study"],"prefix":"10.1111","volume":"152","author":[{"given":"B.","family":"Sol\u00e9","sequence":"first","affiliation":[{"name":"Bipolar and Depressive Disorders Unit Hospital Clinic de Barcelona  Barcelona Spain"},{"name":"Fundaci\u00f3 Cl\u00ednic Per la Recerca Biom\u00e8dica\u2010Institut D'investigacions Biom\u00e8diques August Pi i Sunyer (FCRB\u2010IDIBAPS)  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Montejo","sequence":"additional","affiliation":[{"name":"Bipolar and Depressive Disorders Unit Hospital Clinic de Barcelona  Barcelona Spain"},{"name":"Fundaci\u00f3 Cl\u00ednic Per la Recerca Biom\u00e8dica\u2010Institut D'investigacions Biom\u00e8diques August Pi i Sunyer (FCRB\u2010IDIBAPS)  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Budde","sequence":"additional","affiliation":[{"name":"Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Valent\u00ed","sequence":"additional","affiliation":[{"name":"Bipolar and Depressive Disorders Unit Hospital Clinic de Barcelona  Barcelona Spain"},{"name":"Fundaci\u00f3 Cl\u00ednic Per la Recerca Biom\u00e8dica\u2010Institut D'investigacions Biom\u00e8diques August Pi i Sunyer (FCRB\u2010IDIBAPS)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Borr\u00e0s","sequence":"additional","affiliation":[{"name":"Bipolar and Depressive Disorders Unit Hospital Clinic de Barcelona  Barcelona Spain"},{"name":"Fundaci\u00f3 Cl\u00ednic Per la Recerca 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