{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T07:42:21Z","timestamp":1775893341446,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T00:00:00Z","timestamp":1763856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Antipsychotics are widely used for neuropsychiatric symptoms (NPSs) in dementia including Alzheimer's disease (AD), yet balancing efficacy and safety remains a major clinical challenge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Relevant randomized controlled trials were identified through a comprehensive literature search of CENTRAL, PubMed, CINAHL, and\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      . We conducted a dose\u2013response model\u2010based network meta\u2010analysis to evaluate the efficacy as the change in overall NPS severity and the tolerability as treatment discontinuation due to adverse events of aripiprazole, brexpiprazole, risperidone, quetiapine and olanzapine at varying doses in patients with dementia including AD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty trials involving 5844 participants were included. Most of the included antipsychotics exhibited a generally positive dose\u2013response relationship with respect to both efficacy and tolerability, except for olanzapine, which showed a bell\u2010shaped curve in terms of efficacy. Only aripiprazole 10\u2009mg, brexpiprazole 1\u20132.5\u2009mg, risperidone 1\u20132\u2009mg, and olanzapine 2.5\u20135\u2009mg were significantly more effective than placebo. Tolerability did not significantly decrease compared to placebo for aripiprazole up to 10\u2009mg, brexpiprazole up to 3\u2009mg, risperidone up to 1\u2009mg, olanzapine up to 2.5\u2009mg and at 15\u2009mg, and quetiapine up to 200\u2009mg. Furthermore, significant differences in efficacy and tolerability were observed between certain doses of several antipsychotics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Aripiprazole 10\u2009mg, brexpiprazole 1\u20132.5\u2009mg, risperidone 1\u2009mg, and olanzapine 2.5\u2009mg were both effective and well tolerated, indicating their potential as favorable treatment options. As the present model incorporates several sources of uncertainty, its findings should be interpreted with caution and regarded as a provisional framework to support clinical decision\u2010making.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.70051","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T03:51:05Z","timestamp":1763956265000},"page":"82-94","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparative Efficacy and Tolerability of Multiple Antipsychotics Across Varying Doses for Neuropsychiatric Symptoms of Dementia Including Alzheimer's Disease: A Dose\u2013Response Model\u2010Based Network Meta\u2010Analysis"],"prefix":"10.1111","volume":"153","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0662-5637","authenticated-orcid":false,"given":"Itsuki","family":"Terao","sequence":"first","affiliation":[{"name":"Department of Psychiatry Ikokoro Clinic Nihonbashi  Chuo\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wakako","family":"Kodama","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yu Mental Clinic Ikebukuro  Toshima\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,23]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13809"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000001199"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.05.2410"},{"key":"e_1_2_12_5_1","first-page":"105","article-title":"Neuropsychiatric Symptoms as a Predictor of Caregiver Burden in Alzheimer's Disease","volume":"2","author":"Allegri R. 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