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Studies have reported divergent results concerning cancer\u2010specific mortality. Therefore this systematic review and meta\u2010analysis aimed to assess the cancer\u2010specific mortality for people with preexisting SMD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A comprehensive literature search was conducted across PubMed, Embase, Psycinfo, and Scopus for studies published since January 2003. Inclusion criteria targeted adult cancer patients with a known SMD diagnosis prior to their cancer diagnosis. Two authors independently screened records based on predefined criteria, resolving discrepancies through discussion. Data extraction and quality assessment were conducted using the Newcastle\u2010Ottawa Scale. A random effects model was employed to conduct the analysis, with heterogeneity across the studies quantified using the\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      statistic.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The search yielded 4736 records, of which 25 studies met the eligibility criteria. Findings consistently indicated higher cancer\u2010specific mortality among patients with preexisting SMD, with a 1.37 (95% CI: 1.30\u20131.44) higher relative risk of cancer\u2010specific mortality for patients with preexisting SMD. The highest mortality rates were found among patients with schizophrenia and other psychosis with a relative cancer mortality risk at 1.47 (95% CI: 1.33\u20131.63).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This review and meta\u2010analysis highlighted a concerning higher relative cancer\u2010specific mortality risk for patients with preexisting SMD. These findings underscore the need for integrated healthcare approaches addressing both cancer treatment and mental health to improve outcomes for this vulnerable population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.70054","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T02:32:08Z","timestamp":1764124328000},"page":"158-178","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Impact of Preexisting Severe Mental Disorders on Cancer Mortality: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"153","author":[{"given":"Nikoline","family":"Riis","sequence":"first","affiliation":[{"name":"Department of Oncology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malene","family":"Vestergaard","sequence":"additional","affiliation":[{"name":"Department of Oncology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3309-5838","authenticated-orcid":false,"given":"Mette Asbjoern","family":"Neergaard","sequence":"additional","affiliation":[{"name":"Department of Oncology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Palliative Care Unit, Department of Oncology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Alsner","sequence":"additional","affiliation":[{"name":"Department of Oncology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper Grau","family":"Eriksen","sequence":"additional","affiliation":[{"name":"Department of Oncology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poul","family":"Videbech","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"},{"name":"Center for Neuropsychiatric Depression Research Mental Health Center Glostrup  Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Mygind","sequence":"additional","affiliation":[{"name":"Research Unit for General Practice Aarhus University  Aarhus Denmark"},{"name":"Department of Public Health Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren Paaske","family":"Johnsen","sequence":"additional","affiliation":[{"name":"Danish Center for Health Services Research, Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8205-7179","authenticated-orcid":false,"given":"Jan Brink","family":"Valentin","sequence":"additional","affiliation":[{"name":"Danish Center for Health Services Research, Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise Elkj\u00e6r","family":"Fl\u00f8e","sequence":"additional","affiliation":[{"name":"Department of Oncology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"e_1_2_13_2_1","volume-title":"Guidelines for the Management of Physical Health Conditions in Adults With Severe Mental Disorders","year":"2018"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(17)30429-7"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ags3.12421"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215\u20100366(19)30132\u20104"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(19)32316\u20105"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2004.52018.x"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.117.198952"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.64.2.242"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003583"},{"key":"e_1_2_13_11_1","unstructured":"PROSPERO2023CRD42023475227 accessed January 29 2025 https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?ID=CRD42023475227."},{"key":"e_1_2_13_12_1","unstructured":"G. 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