{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T16:39:33Z","timestamp":1784219973744,"version":"3.55.0"},"reference-count":61,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["T000218N"],"award-info":[{"award-number":["T000218N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to synthesize the evidence on confusional states and neurocognitive changes associated with the concurrent use of lithium and electroconvulsive therapy (ECT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a systematic search of PubMed, EMBASE, Web of Science, Scopus, Cochrane Library, CINAHL, PsycArticles, and clinical trials registries up to September 2025. Eligible studies compared the incidence of confusional states or changes in neurocognitive test scores in patients receiving lithium and ECT (Li\u2010ECT) and those receiving ECT without lithium. We performed separate meta\u2010analyses and calculated odds ratios (OR) with 95% confidence intervals (CI) for dichotomous outcomes and standardized mean differences (SMD) for continuous outcomes. Additionally, case reports describing cognitive effects of Li\u2010ECT were synthesized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixteen studies were included: 11 studies (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200966,156) assessed confusional states and five (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009341) evaluated neurocognitive changes. The Restricted Maximum\u2010Likelihood meta\u2010analysis showed no significant association between lithium use and confusional states (OR 2.09; 95% CI: 0.94\u20134.66;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.07), whereas a Paule\u2010Mandel sensitivity analysis suggested a significant association (OR 2.38; 95% CI: 1.20\u20134.74;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01). No significant differences were observed in changes in global cognitive functioning, autobiographical memory or verbal fluency test scores ([SMD\u2009=\u20090.25; 95% CI: \u20130.98\u20131.49;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.69], [SMD\u2009=\u20090.27; 95% CI: \u22121.37; 1.9;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.75], [SMD\u2009=\u2009\u22120.89; 95% CI: \u22123.18; 1.39;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.44]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Current evidence does not show a significant increase in cognitive side effects associated with lithium use during ECT. However, methodological limitations, sensitivity to meta\u2010analytic assumptions and clinical heterogeneity preclude definitive conclusions. Large prospective studies using standardized cognitive assessments are needed to confirm the tolerability of concurrent lithium and ECT use. While our findings support the cautious continuation of lithium during ECT, individualized clinical decision\u2010making remains crucial to maximize efficacy and minimize cognitive burden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.70095","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T13:36:47Z","timestamp":1775655407000},"page":"116-130","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Lithium, Electroconvulsive Therapy and Cognition: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"154","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4491-3632","authenticated-orcid":false,"given":"Liese","family":"Van den Eynde","sequence":"first","affiliation":[{"name":"Neuropsychiatry, Department of Neurosciences University Psychiatric Center KU Leuven \u2013 University of Leuven, Academic Center for ECT and Neuromodulation (AcCENT)  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2985-6673","authenticated-orcid":false,"given":"Akihiro","family":"Takamiya","sequence":"additional","affiliation":[{"name":"Neuropsychiatry, Department of Neurosciences Leuven Brain Institute, KU Leuven  Leuven Belgium"},{"name":"Hills Joint Research Laboratory for Future Preventive Medicine and Wellness Keio University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristof","family":"Vansteelandt","sequence":"additional","affiliation":[{"name":"Neuropsychiatry, Department of Neurosciences University Psychiatric Center KU Leuven \u2013 University of Leuven, Academic Center for ECT and Neuromodulation (AcCENT)  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6351-1543","authenticated-orcid":false,"given":"Jasmien","family":"Obbels","sequence":"additional","affiliation":[{"name":"Neuropsychiatry, Department of Neurosciences University Psychiatric Center KU Leuven \u2013 University of Leuven, Academic Center for ECT and Neuromodulation (AcCENT)  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Denayer","sequence":"additional","affiliation":[{"name":"Neuropsychiatry, Department of Neurosciences University Psychiatric Center KU Leuven \u2013 University of Leuven, Academic Center for ECT and Neuromodulation (AcCENT)  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shauni","family":"Verspecht","sequence":"additional","affiliation":[{"name":"Neuropsychiatry, Department of Neurosciences University Psychiatric Center KU Leuven \u2013 University of Leuven, Academic Center for ECT and Neuromodulation (AcCENT)  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaat","family":"Hebbrecht","sequence":"additional","affiliation":[{"name":"Neuropsychiatry, Department of Neurosciences University Psychiatric Center KU Leuven \u2013 University of Leuven, Academic Center for ECT and Neuromodulation (AcCENT)  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Sienaert","sequence":"additional","affiliation":[{"name":"Neuropsychiatry, Department of Neurosciences University Psychiatric Center KU Leuven \u2013 University of Leuven, Academic Center for ECT and Neuromodulation (AcCENT)  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,8]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2017.03.052"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199910000-00006"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881118822161"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2021.10.003"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12375"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-020-0683-2"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.08r04972"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2034954"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.2021.37"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/YCT.0000000000000723"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/00048674221089231"},{"key":"e_1_2_14_13_1","first-page":"1","article-title":"Autobiographical Memory After Electroconvulsive Therapy: Systematic Review and Meta\u2010Analysis","volume":"228","author":"Mathiassen A. 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