{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:02:35Z","timestamp":1789747355357,"version":"4.0.1"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T00:00:00Z","timestamp":1782000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T00:00:00Z","timestamp":1782000000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004012","name":"Jane ja Aatos Erkon S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","award":["250038"],"award-info":[{"award-number":["250038"]}],"id":[{"id":"10.13039\/501100004012","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2021\u201000154"],"award-info":[{"award-number":["2021\u201000154"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2026,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Introduction<\/jats:title>\n Diabetes, obesity and bipolar disorder often co\u2010occur and may have shared pathophysiology. Glucagon\u2010like peptide 1 receptor agonists (GLP\u20101RA) treat diabetes and obesity but their impact on bipolar disorder is unknown. In this era of stagnated pharmacotherapy, we examined psychiatric hospitalisation and absence from work due to sick leave as potential measures of relapse in people diagnosed with bipolar disorder who were also prescribed antidiabetic medications, including GLP\u20101RA.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The study cohort was derived from the National Swedish Registers and included all people with a diagnosis of bipolar disorder who used any antidiabetic medication, between the years 2009 and 2024.\n GLP<\/jats:styled-content>\n \u2010\n 1RA<\/jats:styled-content>\n individually and as a group were compared with non\u2010use of\n GLP<\/jats:styled-content>\n \u2010\n 1RA<\/jats:styled-content>\n , and directly with other second\u2010line antidiabetic medications. A within\u2010individual design was utilised for all comparisons to reduce confounding. The main outcome was psychiatric hospitalisation for any reason, with secondary outcomes being psychiatric hospitalisation after a relapse of bipolar disorder, and sick leave due to psychiatric reasons. Within\u2010individual stratified Cox models with adjusted hazard ratios (\n aHRs<\/jats:styled-content>\n ) and 95% confidence intervals (\n CIs<\/jats:styled-content>\n ) were used.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n 14,694 people were included in the study, of whom 5200 used\n GLP<\/jats:styled-content>\n \u2010\n 1RA<\/jats:styled-content>\n . Semaglutide was associated with a 21% (\n aHR<\/jats:styled-content>\n 0.79, 95%\n CI<\/jats:styled-content>\n 0.69\u20130.91) lower risk of psychiatric hospitalisation compared with non\u2010use of\n GLP<\/jats:styled-content>\n \u2010\n 1RA<\/jats:styled-content>\n in that same individual. Liraglutide and dulaglutide were not specifically associated with a lower hospitalisation risk. Semaglutide was also linked to a 17% (\n aHR<\/jats:styled-content>\n 0.83, 95%\n CI<\/jats:styled-content>\n 0.69\u20130.99) lower risk of relapse of bipolar disorder. Absences from work due to sick leave were not significantly associated with the specific antidiabetic medications studied.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n In people with both bipolar disorder and diabetes and\/or obesity, the use of semaglutide was linked to lower rates of psychiatric hospitalisation compared with time periods when GLP\u20101RA were not used by that individual. Liraglutide and dulaglutide were not associated with reduced psychiatric hospitalisation, implying this is not a class effect. This finding with semaglutide should be further tested in a randomised controlled trial.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/acps.70120","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T04:49:37Z","timestamp":1782103777000},"page":"305-312","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Use of Glucagon\u2010Like Peptide 1 Receptor Agonists and the Associated Risk of Hospitalisation in Bipolar Disorder, From a Nationwide Cohort, 2009\u20132024"],"prefix":"10.1111","volume":"154","author":[{"given":"Heidi","family":"Taipale","sequence":"first","affiliation":[{"name":"Department of Forensic Psychiatry University of Eastern Finland, Niuvanniemi Hospital Kuopio Finland"},{"name":"Department of Clinical Neuroscience Karolinska Institutet Stockholm Sweden"},{"name":"Centre for Psychiatry Research Stockholm City Council Stockholm Sweden"},{"name":"School of Pharmacy University of Eastern Finland Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1159-6810","authenticated-orcid":false,"given":"Mark","family":"Taylor","sequence":"additional","affiliation":[{"name":"School of Medicine and Dentistry Griffith University Gold Coast Australia"},{"name":"The Edinburgh Practice Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7244-145X","authenticated-orcid":false,"given":"Markku","family":"L\u00e4hteenvuo","sequence":"additional","affiliation":[{"name":"Department of Forensic Psychiatry University of Eastern Finland, Niuvanniemi Hospital Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellenor","family":"Mittendorfer\u2010Rutz","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antti","family":"Tanskanen","sequence":"additional","affiliation":[{"name":"Department of Forensic Psychiatry University of Eastern Finland, Niuvanniemi Hospital Kuopio Finland"},{"name":"Department of Clinical Neuroscience Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jari","family":"Tiihonen","sequence":"additional","affiliation":[{"name":"Department of Forensic Psychiatry University of Eastern Finland, Niuvanniemi Hospital Kuopio Finland"},{"name":"Department of Clinical Neuroscience Karolinska Institutet Stockholm Sweden"},{"name":"Centre for Psychiatry Research Stockholm City Council Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,21]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44220\u2010025\u201000390\u2010x"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228\u2010025\u201003823\u20109"},{"key":"e_1_2_13_4_1","unstructured":"World Health Organization \u201cDiabetes \u201d2024 https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/diabetes."},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745\u20100179\u20105\u20103"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.14r09635"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2021.12.110"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpsy.2021.11.002"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010025\u201003261\u20100"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201021170\u2010y"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(26)00014-3"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2025.0679"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S116160"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2024.3599"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2023.1078045"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165\u20100327(94)90104\u2010X"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2019.05.052"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010024\u201002498\u20105"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.16626"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010024\u201001931\u2010z"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15682"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1017\/S003329172400299X"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/joccuh\/uiaf067"}],"container-title":["Acta Psychiatrica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acps.70120","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/acps.70120","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acps.70120","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T15:07:58Z","timestamp":1788275278000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acps.70120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,21]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/acps.70120"],"URL":"https:\/\/doi.org\/10.1111\/acps.70120","archive":["Portico"],"relation":{},"ISSN":["0001-690X","1600-0447"],"issn-type":[{"value":"0001-690X","type":"print"},{"value":"1600-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,21]]},"assertion":[{"value":"2026-02-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}