{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T02:09:31Z","timestamp":1789178971533,"version":"build-2803163510"},"reference-count":92,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["U24MH124629"],"award-info":[{"award-number":["U24MH124629"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["U01MH124631"],"award-info":[{"award-number":["U01MH124631"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["U01MH124639"],"award-info":[{"award-number":["U01MH124639"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["220664\/Z\/20\/Z"],"award-info":[{"award-number":["220664\/Z\/20\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["220664\/A\/20\/Z"],"award-info":[{"award-number":["220664\/A\/20\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Suicidal ideation and behaviors (SIB) are common among individuals at clinical high risk for psychosis (CHR\u2010P), but their relationship with the overall clinical profile remains unclear. This study aimed to identify sociodemographic\/clinical factors associated with SIB in CHR\u2010P individuals and to examine whether subthreshold psychotic symptom severity increases with suicidal risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from the AMP SCZ initiative included 1443 CHR\u2010P participants aged 12\u201330\u2009years. SIB were assessed using the Columbia Suicide Severity Rating Scale (C\u2010SSRS). Three Elastic Net regression models examined associations between suicidal ideation severity, intensity, and behaviors using 54 variables spanning sociodemographics, general psychopathology, subthreshold psychotic symptoms, and socio\u2010occupational functioning. Moreover, ANCOVA compared overall psychotic symptom severity across five groups defined by increasing severity on the C\u2010SSRS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixty\u2010eight percent of participants reported lifetime suicidal ideation, and 26% reported previous suicidal behaviors. Model performance was modest but significant (cross\u2010validated ideation severity:\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.161, RMSE\u2009=\u20090.916; ideation intensity:\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.193, RMSE\u2009=\u20090.898; suicidal behavior: accuracy\u2009=\u20090.685; AUC\u2009=\u20090.675;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Across all models, concurrent depressive symptoms, present\/past diagnosis of depression, female sex at birth, cannabis use, visual\/gustatory abnormalities, guilt, and lower role functioning were the most consistent correlates of SIB. Ideation was associated with lower disorganized communication expression and lower negative symptoms, whereas behaviors were associated with schizotypal personality disorder. Other core CHR\u2010P symptoms, including Unusual Thoughts and Experiences, did not contribute to any model. ANCOVA (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001, partial\n                      <jats:italic>\u03b7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.041) indicated increasing overall subthreshold psychotic symptoms across the SIB spectrum.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SIB in CHR\u2010P individuals reflects a multidimensional clinical profile primarily outside of core psychosis\u2010risk symptoms.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      identifier: NCT05905003\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.70138","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T01:49:34Z","timestamp":1789177774000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unraveling Suicidal Ideation and Behaviors in a Global Cohort of Individuals at Clinical High\u2010Risk for Psychosis: Multivariable Correlates and Subthreshold Psychotic Symptoms"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5235-0788","authenticated-orcid":false,"given":"Stefano","family":"Damiani","sequence":"first","affiliation":[{"name":"Department of Brain and Behavioral Sciences University of Pavia  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2783-5262","authenticated-orcid":false,"given":"Marika","family":"Orlandi","sequence":"additional","affiliation":[{"name":"Department of Brain and Behavioral Sciences University of Pavia  Pavia Italy"},{"name":"Child Neurology and Psychiatry Unit IRCCS Mondino Foundation  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9661-4055","authenticated-orcid":false,"given":"Umberto","family":"Provenzani","sequence":"additional","affiliation":[{"name":"Department of Brain and Behavioral Sciences University of Pavia  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Bortolin","sequence":"additional","affiliation":[{"name":"Department of Brain and Behavioral Sciences University of Pavia  Pavia Italy"},{"name":"Universit\u00e0 Vita\u2010Salute San Raffaele  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1312-978X","authenticated-orcid":false,"given":"Margherita","family":"Rovida","sequence":"additional","affiliation":[{"name":"Department of Brain and Behavioral Sciences University of Pavia  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4048-9790","authenticated-orcid":false,"given":"Riccardo","family":"Stefanelli","sequence":"additional","affiliation":[{"name":"Department of Brain and Behavioral Sciences University of Pavia  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8298-0756","authenticated-orcid":false,"given":"Jean","family":"Addington","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Hotchkiss Brain Institute University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Alameda","sequence":"additional","affiliation":[{"name":"Treatment and Early Intervention in Psychosis Program, Service of General Psychiatry Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"},{"name":"Department of Psychosis Studies Institute of Psychiatry, Psychology and Neuroscience, King's College of London  London UK"},{"name":"Centro Investigaci\u00f3n Biomedica en Red de Salud Mental (CIBERSAM), Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocio, Departamento de Psiquiatria Universidad de Sevilla  Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3382-4754","authenticated-orcid":false,"given":"Celso","family":"Arango","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Hospital Universitario La Paz, IdiPAZ, CIBERSAM, School of Medicine Universidad Aut\u00f3noma de  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9877-3719","authenticated-orcid":false,"given":"Nicholas J. 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