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Previous reports indicate that ventral hippocampus\/<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>a1 region plays a critical role in cocaine\u2010, cue\u2010 and context\u2010induced reinstatement of cocaine seeking. Here, we examined whether ventral subiculum, the output region of ventral hippocampus, is involved in context\u2010induced reinstatement of heroin seeking. We found that reversible inactivation of ventral subiculum, but not posterior <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>a1, with the gamma\u2010aminobutyric acid agonists muscimol\u2009+\u2009baclofen decreased context\u2010induced reinstatement of heroin seeking. Our findings, together with previous studies on cocaine seeking, indicate a critical role of ventral subiculum in context\u2010induced relapse across drug classes.<\/jats:p>","DOI":"10.1111\/adb.12015","type":"journal-article","created":{"date-parts":[[2012,12,12]],"date-time":"2012-12-12T08:12:03Z","timestamp":1355299923000},"page":"338-342","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Role of ventral subiculum in context\u2010induced reinstatement of heroin seeking in rats"],"prefix":"10.1111","volume":"19","author":[{"given":"Jennifer M.","family":"Bossert","sequence":"first","affiliation":[{"name":"Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse NIH\/DHHS  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna L.","family":"Stern","sequence":"additional","affiliation":[{"name":"Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse NIH\/DHHS  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,12]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3104"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300977"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3926-07.2007"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2758"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0005-12.2012"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1037\/0097-7403.5.4.368"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-008-1154-3"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2008.0090"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.116.1.169"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2008.06.003"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddmod.2009.03.001"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(87)90275-2"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0600347103"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874941001003020076"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.09.032"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.113.2.283"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2010.10.037"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19980413)393:3<284::AID-CNE2>3.0.CO;2-Y"},{"key":"e_1_2_4_20_1","volume-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos G","year":"2005"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2007.01.003"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902900205"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)91146-8"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-32-10258.2003"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901720104"},{"key":"e_1_2_4_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-002-1337-2"},{"key":"e_1_2_4_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1058043"},{"key":"e_1_2_4_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1973.01750350005001"}],"container-title":["Addiction Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fadb.12015","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.12015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:45:59Z","timestamp":1696466759000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/adb.12015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,12]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1111\/adb.12015"],"URL":"https:\/\/doi.org\/10.1111\/adb.12015","archive":["Portico"],"relation":{},"ISSN":["1355-6215","1369-1600"],"issn-type":[{"value":"1355-6215","type":"print"},{"value":"1369-1600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,12]]},"assertion":[{"value":"2012-12-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}