{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:21:58Z","timestamp":1790616118357,"version":"4.1.0"},"reference-count":63,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,3,7]],"date-time":"2013-03-07T00:00:00Z","timestamp":1362614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neuropsychological studies reported decoding deficits of emotional facial expressions in alcohol\u2010dependent patients, and imaging studies revealed reduced prefrontal and limbic activation during emotional face processing. However, it remains unclear whether this reduced neural activation is mediated by alcohol\u2010associated volume reductions and whether it interacts with treatment outcome. We combined analyses of neural activation during an aversive face\u2010cue\u2010comparison task and local gray matter volumes (<jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content>) using <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>iological <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>arametric <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>apping in 33 detoxified alcohol\u2010dependent patients and 33 matched healthy controls. Alcoholics displayed reduced activation toward <jats:italic>aversive faces\u2013neutral shapes<\/jats:italic> in bilateral fusiform gyrus [<jats:styled-content style=\"fixed-case\">FG<\/jats:styled-content>; <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>rodmann areas (<jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content>) 18\/19], right middle frontal gyrus (<jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content>46\/47), right inferior parietal gyrus (<jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content>7) and left cerebellum compared with controls, which were explained by <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> differences (except for cerebellum). Enhanced functional activation in patients versus controls was found in left rostral anterior cingulate cortex (<jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content>) and medial frontal gyrus (<jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content>10\/11), even after <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> reduction control. Increased <jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content> activation correlated significantly with less (previous) lifetime alcohol intake [<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ifetime <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>rinking <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>istory (<jats:styled-content style=\"fixed-case\">LDH<\/jats:styled-content>)], longer abstinence and less subsequent binge drinking in patients. High <jats:styled-content style=\"fixed-case\">LDH<\/jats:styled-content> appear to impair treatment outcome via its neurotoxicity on <jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content> integrity. Thus, high activation of the rostral <jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content> elicited by affective faces appears to be a resilience factor predicting better treatment outcome. Although no group differences were found, increased <jats:styled-content style=\"fixed-case\">FG<\/jats:styled-content> activation correlated with patients' higher <jats:styled-content style=\"fixed-case\">LDH<\/jats:styled-content>. Because high <jats:styled-content style=\"fixed-case\">LDH<\/jats:styled-content> correlated with worse task performance for facial stimuli in patients, elevated activation in the fusiform \u2018face\u2019 area may reflect inefficient compensatory activation. Therapeutic interventions (e.g. emotion evaluation training) may enable patients to cope with social stress and to decrease relapses after detoxification.<\/jats:p>","DOI":"10.1111\/adb.12045","type":"journal-article","created":{"date-parts":[[2013,3,7]],"date-time":"2013-03-07T13:38:54Z","timestamp":1362663534000},"page":"439-451","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Neural activation during processing of aversive faces predicts treatment outcome in alcoholism"],"prefix":"10.1111","volume":"19","author":[{"given":"Katrin","family":"Charlet","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Campus Mitte Charit\u00e9 Universit\u00e4tsmedizin Berlin  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Schlagenhauf","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Campus Mitte Charit\u00e9 Universit\u00e4tsmedizin Berlin  Germany"},{"name":"Max Planck Institute for Human Cognitive and Brain Sciences  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Richter","sequence":"additional","affiliation":[{"name":"Central Institute of Mental Health  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Naundorf","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Campus Mitte Charit\u00e9 Universit\u00e4tsmedizin Berlin  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Dornhof","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Campus Mitte Charit\u00e9 Universit\u00e4tsmedizin Berlin  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher E. J.","family":"Weinfurtner","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Campus Mitte Charit\u00e9 Universit\u00e4tsmedizin Berlin  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friederike","family":"K\u00f6nig","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Campus Mitte Charit\u00e9 Universit\u00e4tsmedizin Berlin  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadeta","family":"Walaszek","sequence":"additional","affiliation":[{"name":"Physikalisch\u2010Technische Bundesanstalt (PTB)  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Schubert","sequence":"additional","affiliation":[{"name":"Physikalisch\u2010Technische Bundesanstalt (PTB)  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian A.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Campus Mitte Charit\u00e9 Universit\u00e4tsmedizin Berlin  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Gutwinski","sequence":"additional","affiliation":[{"name":"Charit\u00e9 Department of Psychiatry and Psychotherapy St Hedwig Krankenhaus  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Seissinger","sequence":"additional","affiliation":[{"name":"Department of Medical Psychology, Zentrum f\u00fcr Nervenheilkunde Universit\u00e4tsklinikum Bonn  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lioba","family":"Schmitz","sequence":"additional","affiliation":[{"name":"Department of Medical Psychology, Zentrum f\u00fcr Nervenheilkunde Universit\u00e4tsklinikum Bonn  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Walter","sequence":"additional","affiliation":[{"name":"Department of Medical Psychology, Zentrum f\u00fcr Nervenheilkunde Universit\u00e4tsklinikum Bonn  Germany"},{"name":"Division of Mind and Brain Research, Campus Mitte Charit\u00e9 Universit\u00e4tsmedizin Berlin  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Beck","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Campus Mitte Charit\u00e9 Universit\u00e4tsmedizin Berlin  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Gallinat","sequence":"additional","affiliation":[{"name":"Charit\u00e9 Department of Psychiatry and Psychotherapy St Hedwig Krankenhaus  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falk","family":"Kiefer","sequence":"additional","affiliation":[{"name":"Central Institute of Mental Health  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Heinz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Campus Mitte Charit\u00e9 Universit\u00e4tsmedizin Berlin  Germany"},{"name":"Charit\u00e9 Department of Psychiatry and Psychotherapy St Hedwig Krankenhaus  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1996.01830030047008"},{"key":"e_1_2_7_3_1","volume-title":"AUDIT: The Alcohol Use Disorders Identification Test Guidelines for Use in Primary Care","author":"Babor T","year":"2001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.2026"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1961.01710120031004"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.6.961"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291708003991"},{"key":"e_1_2_7_8_1","unstructured":"BrettM AntonJ\u2010L ValabregueR PolineJ\u2010B(2002)Region of interest analysis using an SPM toolbox.Presented at the 8th International Conference on Functional Mapping of the Human Brain June 2\u20106 2002 Sendai Japan. Available on CD\u2010ROM in NeuroImage Vol 16 No 2."},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5364.747"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.09.011"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-28720-6_130"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2006.11.003"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-199302000-00002"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agm020"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2011.01452.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0191-8869(85)90026-1"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1579"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4603(78)90024-2"},{"key":"e_1_2_7_19_1","unstructured":"FirstM SpitzerR GibbonM WilliamsJ(2001)Structured clinical interview for DSM\u2010IV\u2010TR axis I disorders research version patient edition with psychotic screen (SCID\u2010I\/P W\/PSY SCREEN). New York: New York State Psychiatric Institute. NY: Biometrics Research."},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2005.12.008"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(02)00244-5"},{"key":"e_1_2_7_22_1","first-page":"418","article-title":"Functional atlas of emotional faces processing: a voxel\u2010based meta\u2010analysis of 105 functional magnetic resonance imaging studies","volume":"34","author":"Fusar\u2010Poli P","year":"2009","journal-title":"J Psychiatry Neurosci"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.05050.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-004-1828-4"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PSY.0000097348.45087.96"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200001170-00009"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1179"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(02)00373-1"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1364-6613(00)01482-0"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1366"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2007.00406.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3042"},{"key":"#cr-split#-e_1_2_7_33_1.1","unstructured":"HornJL SkinnerHA WarnbergK FosterFMandthe Alcoholism and Drug Addiction Research Foundation(1984)Alcohol Dependence Scale. Toronto"},{"key":"#cr-split#-e_1_2_7_33_1.2","unstructured":"dt. \u00dcbersetzung: Ackermann K Hollweger S & Gordon J (1999). Mannheim Germany: Zentralinstitut f\u00fcr Seelische Gesundheit."},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2222"},{"key":"e_1_2_7_35_1","article-title":"Dopamine\u2010modulated aversive emotion processing fails in alcohol\u2010dependent patients","author":"Kienast T","year":"2013","journal-title":"Pharmacopsychiatry"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1007779107"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/37.4.394"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0193(200007)10:3<120::AID-HBM30>3.0.CO;2-8"},{"key":"e_1_2_7_39_1","volume-title":"Das State\u2010Trait\u2010 Angstinventar (STAI)","author":"Laux L","year":"1981"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2009.01026.x"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1162\/089892902760807212"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(71)90067-4"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agr066"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4679(199511)51:6<768::AID-JCLP2270510607>3.0.CO;2-1"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1072997"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.09.025"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1999.tb04221.x"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2006.07.004"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2008.08020261"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2007.00447.x"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsa.1982.43.1157"},{"key":"e_1_2_7_52_1","volume-title":"Alcohol Timeline Followback User's Manual","author":"Sobell L","year":"1995"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2010.00276.x"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2011.12.011"},{"key":"e_1_2_7_55_1","volume-title":"Co\u2010Planar Stereotaxic Atlas of the Human Brain","author":"Talairach J","year":"1988"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2008.10.016"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3932(02)00284-1"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0978"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2008.02157.x"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006726"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(98)00619-5"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-01-00411.1998"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2008.07121877"}],"container-title":["Addiction Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fadb.12045","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.12045","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:45:50Z","timestamp":1696466750000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/adb.12045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,7]]},"references-count":63,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1111\/adb.12045"],"URL":"https:\/\/doi.org\/10.1111\/adb.12045","archive":["Portico"],"relation":{},"ISSN":["1355-6215","1369-1600"],"issn-type":[{"value":"1355-6215","type":"print"},{"value":"1369-1600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,7]]},"assertion":[{"value":"2013-03-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}