{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T23:49:15Z","timestamp":1782949755429,"version":"3.54.5"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T00:00:00Z","timestamp":1364947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Heroin use among young women of reproductive age has drawn much attention around the world. However, there is lack of information on the long\u2010term effects of prenatal exposure to opioids on their offspring. Our previous study demonstrated that prenatally buprenorphine\u2010exposed offspring showed a marked change in the cross\u2010tolerance to morphine compared with other groups. In the current study, this animal model was used to study effects of methamphetamine (<jats:styled-content style=\"fixed-case\">METH<\/jats:styled-content>)\u2010induced behavioral sensitization in the offspring at their adulthood. The results showed no differences in either basal or acute<jats:styled-content style=\"fixed-case\">METH<\/jats:styled-content>\u2010induced locomotor activity in any of the groups of animals tested. When male offspring received<jats:styled-content style=\"fixed-case\">METH<\/jats:styled-content>injections of 2\u2009mg\/kg, i.p., once a day for 5\u2009days, behavioral sensitization was induced, as determined by motor activity. Furthermore, the distance and rate of development (slope) of locomotor activity and conditioned place preference induced by<jats:styled-content style=\"fixed-case\">METH<\/jats:styled-content>were significantly increased in the prenatally buprenorphine\u2010exposed animals compared with those in other groups. The dopamine<jats:styled-content style=\"fixed-case\"><jats:roman>D<jats:sub>1<\/jats:sub>R<\/jats:roman><\/jats:styled-content>in the nucleus accumbens of the prenatally buprenorphine\u2010exposed offspring had lower<jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>expression; but no significant changes in the \u03bc\u2010, \u03ba\u2010opioid, nociceptin,<jats:styled-content style=\"fixed-case\"><jats:roman>D<jats:sub>2<\/jats:sub>R<\/jats:roman><\/jats:styled-content>and<jats:styled-content style=\"fixed-case\"><jats:roman>D<jats:sub>3<\/jats:sub>R<\/jats:roman><\/jats:styled-content>receptors were noted. Furthermore, significant alterations were observed in the basal level of<jats:styled-content style=\"fixed-case\">cAMP<\/jats:styled-content>and the<jats:styled-content style=\"fixed-case\"><jats:roman>D<jats:sub>1<\/jats:sub>R<\/jats:roman><\/jats:styled-content>agonist enhanced adenylyl cyclase activity in the prenatally buprenorphine\u2010exposed group. Overall, the study demonstrates that<jats:styled-content style=\"fixed-case\"><jats:roman>D<jats:sub>1<\/jats:sub>R<\/jats:roman><\/jats:styled-content>and its downregulated<jats:styled-content style=\"fixed-case\">cAMP<\/jats:styled-content>signals are involved in enhancing<jats:styled-content style=\"fixed-case\">METH<\/jats:styled-content>\u2010induced behavioral sensitization in prenatally buprenorphine\u2010exposed offspring. The study reveals that prenatal exposure to buprenorphine caused long\u2010term effects on offspring and affected the dopaminergic system\u2010related reward mechanism.<\/jats:p>","DOI":"10.1111\/adb.12055","type":"journal-article","created":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T11:25:20Z","timestamp":1364988320000},"page":"676-686","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Development of sensitization to methamphetamine in offspring prenatally exposed to morphine, methadone and buprenorphine"],"prefix":"10.1111","volume":"19","author":[{"given":"Yao\u2010Chang","family":"Chiang","sequence":"first","affiliation":[{"name":"Center for Drug Abuse and Addiction China Medical University Hospital Taiwan"},{"name":"China Medical University Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsai\u2010Wei","family":"Hung","sequence":"additional","affiliation":[{"name":"National 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