{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:39:14Z","timestamp":1791239954258,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T00:00:00Z","timestamp":1383004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ethanol (<jats:styled-content style=\"fixed-case\">EtOH<\/jats:styled-content>)\u2010induced behavioral sensitization (<jats:styled-content style=\"fixed-case\">EIBS<\/jats:styled-content>) is proposed to play a role in early and recurring steps of alcohol dependence, but its impact on alcohol abuse is not clear. <jats:styled-content style=\"fixed-case\">EIBS<\/jats:styled-content> development is dependent upon animal species, strain and also individual factors. We proposed here to decipher the co\u2010expression of <jats:styled-content style=\"fixed-case\">EIBS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">EtOH<\/jats:styled-content> intake in individual animals among outbred <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>wiss mice, which exhibit heterogeneity that parallels what may occur in humans. To do so, mice were exposed to a two\u2010bottle choice with free access to water or 10% <jats:styled-content style=\"fixed-case\">EtOH<\/jats:styled-content> for 6 days just before and immediately after chronic intraperitoneal 2.5\u2009g\/kg ethanol injections once a day for 10 consecutive days. Based on their sensitization scores, mice were split into resistant and sensitized animals. First, we showed that individual susceptibility to <jats:styled-content style=\"fixed-case\">EIBS<\/jats:styled-content> is inversely correlated with voluntary <jats:styled-content style=\"fixed-case\">EtOH<\/jats:styled-content> consumption. Exposure to repeated <jats:styled-content style=\"fixed-case\">EtOH<\/jats:styled-content> during <jats:styled-content style=\"fixed-case\">EIBS<\/jats:styled-content> development increased subsequent <jats:styled-content style=\"fixed-case\">EtOH<\/jats:styled-content> intake among the entire population. Very interestingly, subsequent analyses suggested that the less the mice are sensitized the more they increase their <jats:styled-content style=\"fixed-case\">EtOH<\/jats:styled-content> intake; however, resistant mice were sensitive to <jats:styled-content style=\"fixed-case\">EtOH<\/jats:styled-content> adulteration with quinine, whereas sensitized ones maintained their <jats:styled-content style=\"fixed-case\">EtOH<\/jats:styled-content> intake levels, therefore exhibiting a compulsive\u2010like drinking pattern. In addition, we showed that resistant mice do not exhibit a weaker sensitivity to the aversive properties of <jats:styled-content style=\"fixed-case\">EtOH<\/jats:styled-content> that may contribute to their higher level of <jats:styled-content style=\"fixed-case\">EtOH<\/jats:styled-content> intake compared to sensitized mice. This study confirms and extends previous data showing a deep relationship between propensity for <jats:styled-content style=\"fixed-case\">EtOH<\/jats:styled-content> consumption and susceptibility to <jats:styled-content style=\"fixed-case\">EIBS<\/jats:styled-content> in Swiss mice.<\/jats:p>","DOI":"10.1111\/adb.12104","type":"journal-article","created":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T05:02:42Z","timestamp":1383022962000},"page":"210-224","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Deciphering the relationship between vulnerability to ethanol\u2010induced behavioral sensitization and ethanol consumption in outbred mice"],"prefix":"10.1111","volume":"19","author":[{"given":"R\u00e9mi","family":"Legastelois","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Picardie Jules Verne UFR Pharmacie  INSERM Unit ERi 24 GRAP 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