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The present study sought to determine the role of accumbens core\n mGluR1<\/jats:styled-content>\n ,\n mGluR5<\/jats:styled-content>\n and protein kinase\n C<\/jats:styled-content>\n (\n PKC<\/jats:styled-content>\n ) in cocaine priming\u2010induced reinstatement of drug seeking. Here, we show that intra\u2010accumbens core administration of the\n mGluR1<\/jats:styled-content>\n \/5 agonist\n DHPG<\/jats:styled-content>\n (250\u2009\n \u03bcM<\/jats:styled-content>\n ) promoted cocaine seeking in rats. Consistent with these results, administration of an\n mGluR1<\/jats:styled-content>\n (50.0\u2009\n \u03bcM YM<\/jats:styled-content>\n 298198) or\n mGluR5<\/jats:styled-content>\n (9.0\u2009\n \u03bcM MPEP<\/jats:styled-content>\n ) antagonist directly into the accumbens core prior to a priming injection of cocaine (10\u2009\n mg\/kg<\/jats:styled-content>\n ) attenuated the reinstatement of drug seeking.\n mGluR1<\/jats:styled-content>\n \/5 stimulation activates a signaling cascade including\n PKC<\/jats:styled-content>\n . Intracore microinjection of\n PKC<\/jats:styled-content>\n inhibitors (10\u2009\n \u03bcM R<\/jats:styled-content>\n o 31\u20138220 or 30.0\u2009\n \u03bcM<\/jats:styled-content>\n chelerythrine) also blunted cocaine seeking. In addition, cocaine priming\u2010induced reinstatement of drug seeking was associated with increased phosphorylation of\n PKC\u03b3<\/jats:styled-content>\n , but not\n PKC\u03b1<\/jats:styled-content>\n or\n PKC\u03b2II<\/jats:styled-content>\n , in the core. There were no effects of pharmacological inhibition of\n mGluR1<\/jats:styled-content>\n ,\n mGluR5<\/jats:styled-content>\n or\n PKC<\/jats:styled-content>\n in the accumbens core on sucrose seeking. Together, these findings indicate that\n mGluR1<\/jats:styled-content>\n and\n mGluR5<\/jats:styled-content>\n activation in the accumbens core promotes cocaine seeking and that these effects are reinforcer specific. Furthermore, stimulation of\n mGluR1<\/jats:styled-content>\n and\n mGluR5<\/jats:styled-content>\n in the accumbens core may regulate cocaine seeking, in part, through activation of\n PKC\u03b3<\/jats:styled-content>\n .\n <\/jats:p>","DOI":"10.1111\/adb.12122","type":"journal-article","created":{"date-parts":[[2014,2,9]],"date-time":"2014-02-09T23:10:58Z","timestamp":1391987458000},"page":"285-296","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Group\n I<\/scp>\n metabotropic glutamate receptor\u2010mediated activation of\n PKC<\/scp>\n gamma in the nucleus accumbens core promotes the reinstatement of cocaine seeking"],"prefix":"10.1111","volume":"20","author":[{"given":"Heath D.","family":"Schmidt","sequence":"first","affiliation":[{"name":"Center for Neurobiology and Behavior Department of Psychiatry Perelman School of Medicine University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blake A.","family":"Kimmey","sequence":"additional","affiliation":[{"name":"Center for Neurobiology and Behavior Department of Psychiatry Perelman School of Medicine University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian C.","family":"Arreola","sequence":"additional","affiliation":[{"name":"Center for Neurobiology and Behavior Department of Psychiatry Perelman School of Medicine University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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