{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:41:59Z","timestamp":1791308519410,"version":"4.3.1"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,2,13]],"date-time":"2014-02-13T00:00:00Z","timestamp":1392249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["5R33DA026085"],"award-info":[{"award-number":["5R33DA026085"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR000062"],"award-info":[{"award-number":["UL1TR000062"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["K12HD055885"],"award-info":[{"award-number":["K12HD055885"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The insula has been implicated in cue\u2010induced craving and relapse in nicotine\u2010dependent tobacco cigarette smokers. The aims of the present study were to identify brain regions that exhibit greater functional connectivity with the right anterior insula in response to smoking cues than to neutral cues and the role of functional connectivity between these regions in mediating cue\u2010induced craving in healthy (free of axis\n                    <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\n                    psychiatric disorders) nicotine\u2010dependent tobacco cigarette smokers. Functional magnetic resonance imaging data were collected from 63 healthy nicotine\u2010dependent smokers viewing blocks of smoking and neutral cues. Craving ratings were obtained after each block. A psychophysiologic interaction approach was used to identify regions that exhibited significantly greater functional connectivity with the right anterior insula (seed) during the smoking cues than during the neutral (corrected cluster thresholding, Z\u2009&gt;\u20092.3,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.05). Parameter estimates of the interaction effects from each region were regressed against the mean cue\u2010induced craving scores. Significant task by seed interactions were observed in two clusters centered in the bilateral precuneus and left angular gyrus. The strength of connectivity between the right anterior insula and the precuneus, which is involved interoceptive processing and self\u2010awareness, was positively correlated with the magnitude of the craving response to the smoking cues (\n                    <jats:italic>r<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.15;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.01). These data suggest that among smokers, cue\u2010induced craving may be a function of connectivity between two regions involved in interoception and self\u2010awareness. Moreover, treatment strategies that incorporate mindful attention may be effective in attenuating cue\u2010induced craving and relapse in nicotine\u2010dependent smokers.\n                  <\/jats:p>","DOI":"10.1111\/adb.12124","type":"journal-article","created":{"date-parts":[[2014,2,16]],"date-time":"2014-02-16T20:26:49Z","timestamp":1392582409000},"page":"407-414","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Right anterior insula connectivity is important for cue\u2010induced craving in nicotine\u2010dependent smokers"],"prefix":"10.1111","volume":"20","author":[{"given":"Megan M.","family":"Moran\u2010Santa Maria","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Clinical Neuroscience Division Medical University of South Carolina  Charleston SC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen J.","family":"Hartwell","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Clinical Neuroscience Division Medical University of South Carolina  Charleston SC USA"},{"name":"Ralph H. Johnson VA Medical Center  Charleston SC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen A.","family":"Hanlon","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Clinical Neuroscience Division Medical University of South Carolina  Charleston SC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Canterberry","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Clinical Neuroscience Division Medical University of South Carolina  Charleston SC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Lematty","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Clinical Neuroscience Division Medical University of South Carolina  Charleston SC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Owens","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Clinical Neuroscience Division Medical University of South Carolina  Charleston SC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen T.","family":"Brady","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Clinical Neuroscience Division Medical University of South Carolina  Charleston SC USA"},{"name":"Ralph H. Johnson VA Medical Center  Charleston SC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"George","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Clinical Neuroscience Division Medical University of South Carolina  Charleston SC 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