{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T14:49:06Z","timestamp":1781189346144,"version":"3.54.1"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,7,20]],"date-time":"2014-07-20T00:00:00Z","timestamp":1405814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001443","name":"ABMRF\/The Foundation for Alcohol Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100001443","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Canadian Institutes of Health Research (CIHR)","award":["260418"],"award-info":[{"award-number":["260418"]}]},{"name":"Canadian Institutes of Health Research (CIHR)","award":["288905"],"award-info":[{"award-number":["288905"]}]},{"name":"Canadian Institutes of Health Research (CIHR)","award":["307742"],"award-info":[{"award-number":["307742"]}]},{"name":"NIH","award":["R21 AA020304"],"award-info":[{"award-number":["R21 AA020304"]}]},{"name":"NIH","award":["P60 AA007611"],"award-info":[{"award-number":["P60 AA007611"]}]},{"name":"NIAAA Division of Intramural Clinical and Biological Research"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2016,1]]},"abstract":"Abstract<\/jats:title>Human laboratory and animal models implicate variation in the \u03bc\u2010opioid receptor gene (OPRM1<\/jats:italic><\/jats:styled-content>) as relevant for alcohol\u2010related reward. OPRM1<\/jats:italic><\/jats:styled-content> is associated with alcohol self\u2010administration in non\u2010human primate studies, but the relevance of this finding to human models is unclear. This study used computer\u2010assisted self\u2010infusion of ethanol (CASE<\/jats:styled-content>) to examine associations among OPRM1<\/jats:italic> A118G<\/jats:styled-content> genotype, subjective responses to alcohol and intravenous alcohol self\u2010administration in young heavy drinkers (n<\/jats:italic>\u2009=\u200940, mean age\u2009=\u200919.95 years, SD<\/jats:styled-content>\u2009=\u20090.82). Participants completed a 2\u2010hour CASE<\/jats:styled-content> session comprising a priming phase followed by ad libitum self\u2010administration in a free\u2010access paradigm. Participants achieved a mean peak breath alcohol concentration (BrAC<\/jats:styled-content>) of 81.18\u2009mg% (SD<\/jats:styled-content>\u2009=\u200924.96). Those with the OPRM1<\/jats:italic> 118G<\/jats:styled-content> variant (GA<\/jats:styled-content> or GG<\/jats:styled-content> genotypes) achieved significantly higher peak BrAC<\/jats:styled-content> (M<\/jats:italic>\u2009=\u200994.90\u2009mg%, SD<\/jats:styled-content>\u2009=\u200916.56) than those with the AA<\/jats:styled-content> genotype (M<\/jats:italic>\u2009=\u200974.46\u2009mg%, SD<\/jats:styled-content>\u2009=\u200925.36), reflecting a significantly greater number of alcohol requests among GA<\/jats:styled-content>\/GG<\/jats:styled-content> participants. Eighty percent of GA<\/jats:styled-content>\/GG<\/jats:styled-content> participants surpassed a threshold defining a laboratory analog of heavy alcohol exposure (80\u2009mg%) compared with 46 percent of AA<\/jats:styled-content> participants. Results indicated significant associations between subjective measures of alcohol sensitivity and CASE<\/jats:styled-content> outcomes, although the pattern of findings differed across self\u2010report measures. Subjective responses did not differ by OPRM1<\/jats:italic><\/jats:styled-content> status. These results offer further support for the feasibility of the CASE<\/jats:styled-content> paradigm and provide initial evidence for an association of OPRM1<\/jats:italic><\/jats:styled-content> with alcohol self\u2010administration in a human laboratory context.<\/jats:p>","DOI":"10.1111\/adb.12165","type":"journal-article","created":{"date-parts":[[2014,7,21]],"date-time":"2014-07-21T02:01:57Z","timestamp":1405908117000},"page":"125-135","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Associations of OPRM1<\/i> A118G<\/scp> and alcohol sensitivity with intravenous alcohol self\u2010administration in young adults"],"prefix":"10.1111","volume":"21","author":[{"given":"Christian S.","family":"Hendershot","sequence":"first","affiliation":[{"name":"Campbell Family Mental Health Research Institute Centre for Addiction and Mental Health Canada"},{"name":"Department of Psychiatry University of Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric D.","family":"Claus","sequence":"additional","affiliation":[{"name":"The Mind Research Network and Lovelace Biomedical and Environmental Research Institute Albuquerque NM USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay A.","family":"Ramchandani","sequence":"additional","affiliation":[{"name":"Section on Human Psychopharmacology Laboratory of Clinical and Translational Studies National Institute on Alcohol Abuse and Alcoholism National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2012.01807.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2005.11.024"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.07.026"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.64.3.369"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1037\/0893-164X.21.4.555"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0511(03)00108-X"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1995.tb01554.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2009.00191.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00442016"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1987.tb01263.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000052702.77807.8C"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2008.00692.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3110"},{"key":"e_1_2_6_15_1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.31887\/DCNS.2005.7.2\/lhines","article-title":"Alcoholism: the dissection for endophenotypes","volume":"7","author":"Hines LM","year":"2005","journal-title":"Dialogues Clin Neurosci"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2009.02739.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.11.076"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.26"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2011.01629.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2012.00471.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2009.00192.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.03.006"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2009.12.016"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0034532"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1993.tb00739.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2006.00156.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2008.00135.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/206043a0"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2009.01073.x"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2009.01103.x"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-012-2954-z"},{"key":"e_1_2_6_32_1","unstructured":"National Institute on Alcohol Abuse and Alcoholism(2004)NIAAA Council Approves Definition of Binge Drinking. NIAAA Newsletter: Winter.Available at:http:\/\/pubs.niaaa.nih.gov\/publications\/Newsletter\/winter2004\/Newsletter_Number3.pdf. Accessed 23 December 2013."},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130100919"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300219"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2008.919132"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2012.01885.x"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2011.01704.x"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1999.tb04163.x"},{"key":"e_1_2_6_39_1","first-page":"286","article-title":"Studying alcohol elimination using the alcohol clamp method","volume":"29","author":"Ramchandani VA","year":"2006","journal-title":"Alcohol Res Health"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2009.00906.x"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2010.56"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000148114.34000.B9"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.64.9.1069"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2011.01633.x"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.192"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161210791516422"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.1993.tb02093.x"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2011.01446.x"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-0357-5_3"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2006.00258.x"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2010.01.005"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2008.00454.x"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-008-1349-7"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2008.00700.x"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-28720-6_149"}],"container-title":["Addiction Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fadb.12165","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.12165","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T02:56:56Z","timestamp":1696388216000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/adb.12165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,20]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1111\/adb.12165"],"URL":"https:\/\/doi.org\/10.1111\/adb.12165","archive":["Portico"],"relation":{},"ISSN":["1355-6215","1369-1600"],"issn-type":[{"value":"1355-6215","type":"print"},{"value":"1369-1600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,20]]},"assertion":[{"value":"2014-07-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}