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As of 2013, <jats:styled-content style=\"fixed-case\"><jats:italic>A<\/jats:italic><\/jats:styled-content><jats:italic>ddiction<\/jats:italic>\u2005<jats:styled-content style=\"fixed-case\"><jats:italic>B<\/jats:italic><\/jats:styled-content><jats:italic>iology<\/jats:italic> is ranked number 1 in the category of <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ubstance <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>buse journals (<jats:styled-content style=\"fixed-case\">SCI<\/jats:styled-content>). Occasionally, <jats:styled-content style=\"fixed-case\"><jats:italic>A<\/jats:italic><\/jats:styled-content><jats:italic>ddiction<\/jats:italic>\u2005<jats:styled-content style=\"fixed-case\"><jats:italic>B<\/jats:italic><\/jats:styled-content><jats:italic>iology<\/jats:italic> likes to highlight via review important findings focused on a particular topic and recently published in the journal. The current review summarizes a number of key publications from <jats:styled-content style=\"fixed-case\"><jats:italic>A<\/jats:italic><\/jats:styled-content><jats:italic>ddiction<\/jats:italic>\u2005<jats:styled-content style=\"fixed-case\"><jats:italic>B<\/jats:italic><\/jats:styled-content><jats:italic>iology<\/jats:italic> that have contributed to the current knowledge of nicotine research, comprising a wide spectrum of approaches, both clinical and pre\u2010clinical, at the cellular, molecular, systems and behavioral levels. A number of findings from human studies have identified, using imaging techniques, alterations in common brain circuits, as well as morphological and network activity changes, associated with tobacco use. Furthermore, both clinical and pre\u2010clinical studies have characterized a number of mechanistic targets critical to understanding the effects of nicotine and tobacco addiction. 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