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Although <jats:styled-content style=\"fixed-case\">IGA<\/jats:styled-content> induces a variety of negative psychosocial consequences, it is yet ambiguous whether the brain addicted to <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>nternet gaming is considered to be in a pathological state. We investigated <jats:styled-content style=\"fixed-case\">IGA<\/jats:styled-content>\u2010induced abnormalities of the brain specifically from the network perspective and qualitatively assessed whether the <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>nternet gaming\u2010addicted brain is in a state similar to the pathological brain. Topological properties of brain functional networks were examined by applying a graph\u2010theoretical approach to analyzing functional magnetic resonance imaging data acquired during a resting state in 19 <jats:styled-content style=\"fixed-case\">IGA<\/jats:styled-content> adolescents and 20 age\u2010matched healthy controls. We compared functional distance\u2010based measures, global and local efficiency of resting state brain functional networks between the two groups to assess how the <jats:styled-content style=\"fixed-case\">IGA<\/jats:styled-content> subjects' brain was topologically altered from the controls' brain. The <jats:styled-content style=\"fixed-case\">IGA<\/jats:styled-content> subjects had severer impulsiveness and their brain functional networks showed higher global efficiency and lower local efficiency relative to the controls. These topological differences suggest that <jats:styled-content style=\"fixed-case\">IGA<\/jats:styled-content> induced brain functional networks to shift toward the random topological architecture, as exhibited in other pathological states. Furthermore, for the <jats:styled-content style=\"fixed-case\">IGA<\/jats:styled-content> subjects, the topological alterations were specifically attributable to interregional connections incident on the frontal region, and the degree of impulsiveness was associated with the topological alterations over the frontolimbic connections. The current findings lend support to the proposition that the <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>nternet gaming\u2010addicted brain could be in the state similar to pathological states in terms of topological characteristics of brain functional networks.<\/jats:p>","DOI":"10.1111\/adb.12282","type":"journal-article","created":{"date-parts":[[2015,7,2]],"date-time":"2015-07-02T02:22:59Z","timestamp":1435803779000},"page":"196-205","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Is the <scp>I<\/scp>nternet gaming\u2010addicted brain close to be in a pathological state?"],"prefix":"10.1111","volume":"22","author":[{"given":"Chang\u2010hyun","family":"Park","sequence":"first","affiliation":[{"name":"Department of Neurology Ewha Medical Research Institute Ewha Womans University School of Medicine  Seoul 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