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However, unlike other psychostimulants, the addictive potential of cathinone derivatives has not been widely studied. Here, we investigated the effects of pentedrone, a type of cathinone derivative, on the dopaminergic system using reverse transcription polymerase chain reaction and Western blot. We also evaluated the addictive potential of pentedrone using conditioned place preference and self\u2010administration. We found that pentedrone increased the mRNA expression of dopamine 1 receptor, dopamine 2 receptor and dopamine transporter, as well as induced phosphorylation of cAMP response element\u2010binding protein in PC\u201012 cells. Additionally, pentedrone at 3 and 10\u2009mg\/kg significantly increased conditioned place preference in mice, while pentedrone at 0.3\u2009mg\/kg\/infusion significantly increased self\u2010administration in rats. Finally, we found that acute administration of pentedrone enhanced locomotor activity in a dose\u2010dependent manner. Collectively, these data suggest that the addictive properties of pentedrone may be due to its effects on the dopaminergic system.<\/jats:p>","DOI":"10.1111\/adb.12299","type":"journal-article","created":{"date-parts":[[2015,8,20]],"date-time":"2015-08-20T05:13:42Z","timestamp":1440047622000},"page":"117-128","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The new stimulant designer compound pentedrone exhibits rewarding properties and affects dopaminergic activity"],"prefix":"10.1111","volume":"22","author":[{"given":"Ji\u2010Young","family":"Hwang","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy Sungkyunkwan University  Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun\u2010Sub","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy Sungkyunkwan University  Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji\u2010Hwan","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy Sungkyunkwan University  Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sa\u2010Ik","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy Sungkyunkwan University  Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi\u2010Xun","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy Sungkyunkwan University  Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang\u2010Hee","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy Sungkyunkwan University  Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong\u2010Hyun","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy Sungkyunkwan University  Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seok\u2010Yong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy Sungkyunkwan University  Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyoung\u2010Chun","family":"Kim","sequence":"additional","affiliation":[{"name":"Neurotoxicology Program, College of Pharmacy, Korea Institute of Drug Abuse Kangwon National University  Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Choon\u2010Gon","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy Sungkyunkwan University  Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,8,19]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12038"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2013.04.003"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2008.06369.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2012.02214.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.304"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-007-0790-3"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2011.00428.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12061"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2014.039"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2015.01.003"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfu108"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-014-3737-5"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.03.015"},{"key":"e_1_2_5_15_1","unstructured":"Food and Drug Administration (FDA)\/Center for Drug Evaluation and Research (CDER)(2010)Draft Guidance for Industry: Assessment of Abuse Potential of Drugs. 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