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A detrimental effect of cocaine on blood\u2013brain barrier (BBB) integrity has also been reported. This study evaluates the effects of repeated social defeat (RSD) during adolescence on the reinforcing and motivational effects of cocaine in adult mice and the changes induced by RSD on BBB permeability. Cocaine self\u2010administration, conditioned place preference and quantitative analysis of claudin\u20105, laminin, collagen\u2010IV and IgG immunoreactivity took place 3\u2009weeks after RSD. Mice socially defeated during adolescence developed conditioned place preference and exhibited reinstated preference with a non\u2010effective dose of cocaine (1\u2009mg\/kg). RSD mice needed significantly more sessions than control animals for the preference induced by 25\u2009mg\/kg of cocaine to be extinguished. However, acquisition of cocaine self\u2010administration (0.5\u2009mg\/kg per injection) was delayed in the RSD group. Mice exposed to RSD displayed significant changes in BBB structure in adulthood, with a marked reduction in expression of the tight junction protein claudin\u20105 and an increase in basal laminin degradation (reflected by a decrease in laminin and collagen\u2010IV expression) in the nucleus accumbens and hippocampus. The detrimental effect induced by cocaine (25\u2009mg\/kg) on collagen\u2010IV expression in the hippocampus was more pronounced in RSD mice. In summary, our findings suggest that stress and cocaine can increase the long\u2010term vulnerability of the brain to subsequent environmental insults as a consequence of a sustained disruption of the BBB.<\/jats:p>","DOI":"10.1111\/adb.12301","type":"journal-article","created":{"date-parts":[[2015,9,16]],"date-time":"2015-09-16T06:25:12Z","timestamp":1442384712000},"page":"129-141","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Effects of repeated social defeat on adolescent mice on cocaine\u2010induced CPP and self\u2010administration in adulthood: integrity of the blood\u2013brain barrier"],"prefix":"10.1111","volume":"22","author":[{"given":"Marta","family":"Rodr\u00edguez\u2010Arias","sequence":"first","affiliation":[{"name":"Unidad de Investigaci\u00f3n Psicobiolog\u00eda de las Drogodependencias, Departamento de Psicobiolog\u00eda, Facultad de Psicolog\u00eda Universitat de Val\u00e8ncia  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