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We have recently reported that increased basal regional cerebral blood flow (rCBF) in a pHp loci, as measured by pseudo\u2010continuous arterial spin labeling magnetic resonance imaging, predicted days to cocaine relapse following residential treatment. In this secondary analysis, we explored whether rCBF in this same pHp region would successfully predict 30\u2010day point prevalence abstinence 60\u2009days following residential treatment in an independent group of previously studied participants with cocaine dependence. rCBF was assessed with single photon emission computerized tomography during a saline infusion in 21 cocaine dependence and 22 healthy control participants. pHp rCBF was significantly higher in those endorsing substance use (<jats:italic>n<\/jats:italic>\u2009=\u200910) relative to both abstinent (<jats:italic>n<\/jats:italic>\u2009=\u200911) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and control (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) participants. There were no significant differences in measured demographic or clinical variables between the actively using and non\u2010using participants. This replicative finding suggests that heightened pHp activation is a significant predictor of substance use in cocaine\u2010dependent individuals, possibly reflecting a neural susceptibility to continued drug cues.<\/jats:p>","DOI":"10.1111\/adb.12361","type":"journal-article","created":{"date-parts":[[2016,1,11]],"date-time":"2016-01-11T09:20:32Z","timestamp":1452504032000},"page":"857-863","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Posterior hippocampal regional cerebral blood flow predicts abstinence: a replication study"],"prefix":"10.1111","volume":"22","author":[{"given":"Bryon","family":"Adinoff","sequence":"first","affiliation":[{"name":"VA North Texas Health Care System  Dallas TX USA"},{"name":"Department of Psychiatry UT Southwestern Medical Center  Dallas TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas 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