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Here, we characterized the temporal profile of neuroinflammation in rats exposed to intragastric binge ethanol administrations (3 times\/day\u2009\u00d7\u20094\u2009days) and tested the anti\u2010inflammatory\/neuroprotective properties of the satiety factor oleoylethanolamide (OEA). Pre\u2010treatment with OEA (5 mg\/kg, i.p.) previous each alcohol gavage blocked the expression of high mobility group box 1 (HMGB1) danger signal and the innate immunity Toll\u2010like receptors 4 (TLR4) in frontal cortex, and inhibited the nuclear factor\u2010kappa B (NF\u2010kB) proinflammatory cascade induced by alcohol binge administration. OEA reduced the levels of interleukin\u20101beta (IL\u20101\u03b2), the monocyte chemoattractant protein\u20101 (MCP\u20101), and the enzymes cyclooxygenase\u20102 (COX\u20102) and inducible nitric oxide synthase (iNOS) in ethanol binged animals. Elevations in plasma tumor necrosis factor alpha (TNF\u2010\u03b1) and IL\u20101\u03b2 after ethanol were also inhibited by OEA. OEA also prevented ethanol\u2010induced lipid peroxidation, caspase\u20108 and pro\u2010apoptotic caspase\u20103 activation in frontal cortex. Additionally, OEA blocked the rise in blood corticosterone levels after ethanol with no alteration in blood ethanol levels and may affect ethanol\u2010induced gut permeability for endotoxin. Finally, OEA, administered as a pre\u2010treatment during the ethanol binge, exerted antidepressant\u2010like effects during acute withdrawal. Altogether, results highlight a beneficial profile of OEA as a potent anti\u2010inflammatory, antioxidant, neuroprotective and antidepressant\u2010like compound to treat alcohol abuse.<\/jats:p>","DOI":"10.1111\/adb.12365","type":"journal-article","created":{"date-parts":[[2016,2,9]],"date-time":"2016-02-09T08:53:44Z","timestamp":1455008024000},"page":"724-741","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":100,"title":["Oleoylethanolamide prevents neuroimmune HMGB1\/TLR4\/NF\u2010kB danger signaling in rat frontal cortex and depressive\u2010like behavior induced by ethanol binge administration"],"prefix":"10.1111","volume":"22","author":[{"given":"Mar\u00eda","family":"Ant\u00f3n","sequence":"first","affiliation":[{"name":"Department of Psychobiology, Faculty of Psychology Complutense University  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