{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:22:28Z","timestamp":1791289348216,"version":"4.3.0"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,3,9]],"date-time":"2016-03-09T00:00:00Z","timestamp":1457481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Natural Scientific Foundation of China","award":["81201084"],"award-info":[{"award-number":["81201084"]}]},{"name":"Natural Scientific Foundation of China","award":["81560283"],"award-info":[{"award-number":["81560283"]}]},{"name":"Natural Scientific Foundation of Jiangxi Province, China","award":["20151BAB205049"],"award-info":[{"award-number":["20151BAB205049"]}]},{"name":"Planned Science and Technology Project of Guangdong Province","award":["2011B031800044"],"award-info":[{"award-number":["2011B031800044"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Models of heroin addiction emphasize the role of disrupted frontostriatal circuitry supporting cognitive control processes. However, heroin addiction\u2010related alterations in functional and structural interactions among brain regions, especially between the cerebral hemispheres, are rarely examined directly. Resting\u2010state functional magnetic resonance imaging (fMRI) approaches, which reveal patterns of coherent spontaneous fluctuations in the fMRI signal, offer a means to quantify directly functional interactions between the hemispheres. The corpus callosum (CC), which connects homologous regions of the cortex, is the major conduit for information transfer between the cerebral hemispheres and represents a structural connectivity index between hemispheres. We compared interhemispheric voxel\u2010mirrored homotopic connectivity (VMHC) and CC volume between 45 heroin dependent\u2010individuals (HDIs) and 35 non\u2010addict individuals. We observed significant reduction of VMHC in a number of regions, particularly the striatum\/limbic system regions, and significant decrease in splenium and genu sub\u2010regions of CC in HDI. Importantly, within HDI, VMHC in the dorsal lateral prefrontal cortex (DLPFC) correlated with genu CC volume, VMHC in the putamen, VMHC in the DLPFC and genu CC volume and splenium CC volume were negatively correlated with heroin duration and impulsivity traits. Further analyses demonstrated that impairment of VMHC of bilateral DLPFC partially mediated the association between genu CC volumes decreased and increased impulsivity in HDI. Our results reveal a substantial impairment of interhemispheric coordination in the HDI. Further, interhemispheric connectivity correlated with the duration of heroin abuse and higher impulsivity behavior in HDI. Our findings provide insight into a heroin addicts' related pathophysiology and reinforce an integrative view of the interhemispheric cerebral functional and structural organization.<\/jats:p>","DOI":"10.1111\/adb.12387","type":"journal-article","created":{"date-parts":[[2016,3,12]],"date-time":"2016-03-12T07:05:06Z","timestamp":1457766306000},"page":"1057-1067","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Aberrant interhemispheric functional and structural connectivity in heroin\u2010dependent individuals"],"prefix":"10.1111","volume":"22","author":[{"given":"Ying\u2010wei","family":"Qiu","sequence":"first","affiliation":[{"name":"Department of Medical Imaging Guangdong No.2 Provincial People's Hospital  China"},{"name":"Center for Cognitive Neuroscience, Neuroscience and Behavioral Disorders Program Duke\u2010National University of Singapore Graduate Medical School  Singapore"},{"name":"Department of Medical Imaging, Zhongshan Ophthalmic Center Sun Yat\u2010sen University  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui\u2010hua","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Guangdong No.2 Provincial People's Hospital  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010fen","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Guangdong No.2 Provincial People's Hospital  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan\u2010Huan","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Guangdong No.2 Provincial People's Hospital  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010fei","family":"Lv","sequence":"additional","affiliation":[{"name":"Sun Yat\u2010sen University Cancer Center State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu\u2010zhen","family":"Zhuo","sequence":"additional","affiliation":[{"name":"Addiction Medicine Division Guangdong No.2 Provincial People's Hospital  China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,9]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"(2014)United Nations Office on Drugs and Crime The World Drug Report of 2014. 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