{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:44:27Z","timestamp":1789685067406,"version":"4.0.1"},"reference-count":59,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T00:00:00Z","timestamp":1458604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Addiction is a chronic brain disorder that progressively invades all aspects of personal life. Accordingly, addiction to opiates severely impairs interpersonal relationships, and the resulting social isolation strongly contributes to the severity and chronicity of the disease. Uncovering new therapeutic strategies that address this aspect of addiction is therefore of great clinical relevance. We recently established a mouse model of heroin addiction in which, following chronic heroin exposure, \u2018abstinent\u2019 mice progressively develop a strong and long\u2010lasting social avoidance phenotype. Here, we explored and compared the efficacy of two pharmacological interventions in this mouse model. Because clinical studies indicate some efficacy of antidepressants on emotional dysfunction associated with addiction, we first used a chronic 4\u2010week treatment with the serotonergic antidepressant fluoxetine, as a reference. In addition, considering prodepressant effects recently associated with kappa opioid receptor signaling, we also investigated the kappa opioid receptor antagonist norbinaltorphimine (norBNI). Finally, we assessed whether fluoxetine and norBNI could reverse abstinence\u2010induced social avoidance after it has established. Altogether, our results show that two interspaced norBNI administrations are sufficient both to prevent and to reverse social impairment in heroin abstinent animals. Therefore, kappa opioid receptor antagonism may represent a useful approach to alleviate social dysfunction in addicted individuals.<\/jats:p>","DOI":"10.1111\/adb.12392","type":"journal-article","created":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T12:33:25Z","timestamp":1458650005000},"page":"1010-1021","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Kappa opioid receptor antagonism and chronic antidepressant treatment have beneficial activities on social interactions and grooming deficits during heroin abstinence"],"prefix":"10.1111","volume":"22","author":[{"given":"L.","family":"Lalanne","sequence":"first","affiliation":[{"name":"Translational Medicine and Neurogenetics Department, Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, INSERM U 964, CNRS UMR 7104 Universit\u00e9 de Strasbourg France"},{"name":"D\u00e9partement de Psychiatrie I, H\u00f4pital Civil Centre Hospitalier R\u00e9gional Universitaire de Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Ayranci","sequence":"additional","affiliation":[{"name":"Translational Medicine and Neurogenetics Department, Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, INSERM U 964, CNRS UMR 7104 Universit\u00e9 de Strasbourg France"},{"name":"Douglas Institute Research Centre McGill University Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Filliol","sequence":"additional","affiliation":[{"name":"Translational Medicine and Neurogenetics Department, Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, INSERM U 964, CNRS UMR 7104 Universit\u00e9 de Strasbourg France"},{"name":"Laboratoire de Neurosciences Cognitives et Adaptatives, UMR 7364 Universit\u00e9 de Strasbourg, CNRS, Facult\u00e9 de Psychologie, Neurop\u00f4le de Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Gav\u00e9riaux\u2010Ruff","sequence":"additional","affiliation":[{"name":"Translational Medicine and Neurogenetics Department, Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, INSERM U 964, CNRS UMR 7104 Universit\u00e9 de Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Befort","sequence":"additional","affiliation":[{"name":"Translational Medicine and Neurogenetics Department, Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, INSERM U 964, CNRS UMR 7104 Universit\u00e9 de Strasbourg France"},{"name":"Laboratoire de Neurosciences Cognitives et Adaptatives, UMR 7364 Universit\u00e9 de Strasbourg, CNRS, Facult\u00e9 de Psychologie, Neurop\u00f4le de Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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