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To evaluate putative treatment mechanisms, human laboratory studies have examined naltrexone's effects on alcohol responses and self\u2010administration during short\u2010term medication protocols. Results from these studies are inconsistent and have yet to be examined in aggregate. This meta\u2010analysis aimed to quantify naltrexone's effects on alcohol self\u2010administration and craving in the context of placebo\u2010controlled human laboratory trials. Potential moderators of medication effects were also examined. Meta\u2010analyses of alcohol self\u2010administration (\n                    <jats:italic>k<\/jats:italic>\n                    \u2009=\u20099,\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009490) and craving (\n                    <jats:italic>k<\/jats:italic>\n                    \u2009=\u200916,\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009748) confirmed that, under controlled experimental conditions, naltrexone reduces the quantity of consumption (Hedges'\n                    <jats:italic>g<\/jats:italic>\n                    \u2009=\u2009\u2212.277, SE\u2009=\u2009.074, 95 percent CI\u2009=\u2009\u2212.421, \u2212.133,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.001) and magnitude of self\u2010reported craving (\n                    <jats:italic>g<\/jats:italic>\n                    \u2009=\u2009\u2212.286, SE\u2009=\u2009.066, 95 percent CI\u2009=\u2009\u2212.416, \u2212.156,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.001) relative to placebo. Subgroup and moderation analyses found no evidence that effect sizes differed by study population (dependent versus non\u2010dependent drinkers), laboratory paradigm or duration of medication exposure. These results substantiate prior evidence for reductions in event\u2010level craving and consumption as potential treatment mediators, also establishing effect sizes to inform future human laboratory trials. From a clinical perspective, these results may provide additional evidence regarding naltrexone's efficacy in the context of acute or subacute dosing regimens.\n                  <\/jats:p>","DOI":"10.1111\/adb.12425","type":"journal-article","created":{"date-parts":[[2016,7,14]],"date-time":"2016-07-14T06:50:42Z","timestamp":1468479042000},"page":"1515-1527","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":90,"title":["Effects of naltrexone on alcohol self\u2010administration and craving: meta\u2010analysis of human laboratory studies"],"prefix":"10.1111","volume":"22","author":[{"given":"Christian S.","family":"Hendershot","sequence":"first","affiliation":[{"name":"Campbell Family Mental Health Research Institute Centre for Addiction and Mental Health  Canada"},{"name":"Department of Psychiatry, University of Toronto  Canada"},{"name":"Department of Psychology University of Toronto  Canada"},{"name":"Institute for Mental 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