{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:10:43Z","timestamp":1790813443622,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,9,5]],"date-time":"2016-09-05T00:00:00Z","timestamp":1473033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NWO\/ZonMW VENI","award":["#016.126.059"],"award-info":[{"award-number":["#016.126.059"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Genetic variations in the mu\u2010opioid receptor (<jats:italic>OPRM1<\/jats:italic>) gene have been related to high sensitivity to rewarding effects of alcohol. The current study focuses on the neural circuitry underlying this phenomenon using an alcohol versus water taste\u2010cue reactivity paradigm in a young sample at relatively early stages of alcohol use, thus limiting the confound of variations in duration of alcohol use. Drinkers (17\u201321\u2009years old) were selected on genotype carrying the AA\u2014(<jats:italic>n<\/jats:italic>\u2009=\u200920) or the AG\u2014(<jats:italic>n<\/jats:italic>\u2009=\u200916) variant of the A118G single nucleotide polymorphism (SNP) of the <jats:italic>OPRM1<\/jats:italic> gene (rs1799971), and underwent functional magnetic resonance imaging (fMRI). Magnitude of the neural activity and frontostriatal functional connectivity in response to alcohol versus water were investigated. The AG\u2010group demonstrated reduced activation in prefrontal and parietal regions, including the inferior and middle frontal gyrus, superior and inferior parietal lobule, compared with the AA\u2010group. No activation differences were observed in the mesolimbic pathway. Connectivity from the ventral\u2010striatum to frontal regions for alcohol\u2009&gt;\u2009water trials was higher in the AG than the AA group. For the dorsal\u2010striatum seed region, the AG group showed increased connectivity to non\u2010PFC regions. These results indicate that adolescents carrying the G\u2010allele may be more vulnerable for the alcohol to hijack the reward system in the absence of frontal control to regulate craving. This implies that findings of hyperactivation in the mesolimbic structures of G\u2010allele carriers in earlier studies might result from both genetic susceptibility and heavy drinking.<\/jats:p>","DOI":"10.1111\/adb.12440","type":"journal-article","created":{"date-parts":[[2016,9,5]],"date-time":"2016-09-05T05:32:59Z","timestamp":1473053579000},"page":"1562-1575","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Neural response to alcohol taste cues in youth: effects of the <i>OPRM1<\/i> gene"],"prefix":"10.1111","volume":"22","author":[{"given":"Ozlem","family":"Korucuoglu","sequence":"first","affiliation":[{"name":"Addiction, Development and Psychopathology (ADAPT)\u2010lab, Department of Psychology University of Amsterdam  The Netherlands"},{"name":"Department of Psychological Sciences University of Missouri  Columbia MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Gladwin","sequence":"additional","affiliation":[{"name":"Addiction, Development and Psychopathology (ADAPT)\u2010lab, Department of Psychology University of Amsterdam  The Netherlands"},{"name":"Research Centre \u2013 Military Mental Health Ministry of Defense  The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Baas","sequence":"additional","affiliation":[{"name":"Department of Genome Analysis Academic Medical Centre  The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roel J.T.","family":"Mocking","sequence":"additional","affiliation":[{"name":"Program for Mood Disorders, Department of Psychiatry, Academic Medical Center University of Amsterdam  The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henricus G.","family":"Ruh\u00e9","sequence":"additional","affiliation":[{"name":"Program for Mood Disorders, Department of Psychiatry, Academic Medical Center University of Amsterdam  The Netherlands"},{"name":"University of Groningen, University Medical Center Groningen, Mood and Anxiety Disorders Department of Psychiatry  The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul F.C.","family":"Groot","sequence":"additional","affiliation":[{"name":"Department of Radiology Academic Medical Center  The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinout W.","family":"Wiers","sequence":"additional","affiliation":[{"name":"Addiction, Development and Psychopathology (ADAPT)\u2010lab, Department of Psychology University of Amsterdam  The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00491-3"},{"key":"e_1_2_6_3_1","unstructured":"Alem\u00e1n\u2010G\u00f3mezY Melie\u2010Garc\u00edaL Valdes\u2010Hern\u00e1ndezP(2006) IBASPM: Toolbox for automatic parcellation of brain structures.\u00a0Present 12th Annu Meet Organ Hum Brain Mapping June 11\u2013 15 2006 Florence Italy Available CD\u2010Rom NeuroImage."},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-08-02793.2001"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(03)00233-9"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2008.12.014"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161212798919110"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.16.9608"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.99"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsad.2014.75.124"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.12.034"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2008.0089"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2010.03.001"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2010.04.008"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301513"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2008.00692.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2008.06.027"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1997.0291"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2011.06.008"},{"key":"e_1_2_6_20_1","unstructured":"GladwinTE VinkM(2008).hiro3 [Computer Software]. 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