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In this study, the Netrin G1 (<jats:italic>Ntng1<\/jats:italic>) expression was investigated in the nucleus accumbens of mice primarily conditioned to cocaine using a place preference paradigm. A genetic association study was then conducted on 146 multiplex families of the Collaborative study on Genetics of Alcoholism, in which seven single nucleotide polymorphisms located in the<jats:italic>NTNG1<\/jats:italic>gene were genotyped.<jats:italic>NTNG1<\/jats:italic>expression levels were also quantified in BA10, BA46 and the cerebellum of healthy controls (with no Axis 1 psychopathology). Decreased<jats:italic>Ntng1<\/jats:italic>expression was initially observed in the nucleus accumbens of mice conditioned to cocaine. Significant genetic family\u2010based associations were detected between<jats:italic>NTNG1<\/jats:italic>polymorphisms and cocaine dependence.<jats:italic>NTNG1<\/jats:italic>expression in BA10, BA46 and the cerebellum, however, were not significantly associated with any allele or haplotype of this gene. These results confirm that<jats:italic>Ntng1<\/jats:italic>expression is disturbed in the nucleus accumbens of mice, after cocaine conditioning. A haplotype of<jats:italic>NTNG1<\/jats:italic>was found to constitute a vulnerability factor for cocaine use disorder in patients, although none of its single nucleotide polymorphisms were associated with a differential expression pattern in healthy controls. The data suggest that change in the<jats:italic>Ntng1<\/jats:italic>expression is a consequence of cocaine exposure, and that some of its genetic markers are associated with a greater risk for cocaine use disorder.<\/jats:p>","DOI":"10.1111\/adb.12485","type":"journal-article","created":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T07:12:57Z","timestamp":1484118777000},"page":"448-460","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Netrin G1: its downregulation in the nucleus accumbens of cocaine\u2010conditioned mice and genetic association in human cocaine dependence"],"prefix":"10.1111","volume":"23","author":[{"given":"Sabah","family":"Kela\u00ef","sequence":"first","affiliation":[{"name":"INSERM U894, Centre de Psychiatrie &amp; Neurosciences University Paris Descartes Paris 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