{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:02:46Z","timestamp":1791198166783,"version":"4.1.0"},"reference-count":69,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T00:00:00Z","timestamp":1487808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["."],"award-info":[{"award-number":["."]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cocaine addiction is a multi\u2010dimensional behavioral disorder characterized by a loss of control over cocaine taking despite of detrimental consequences. Structural MRI studies have revealed association between cocaine consumption and gray matter volume (GMV) in cocaine\u2010addicted patients. However, the behavioral correlates of GMV in cocaine addiction are poorly understood. Here, we used a DSM\u2010IV\u2010based rat model of cocaine addiction with high face validity for structural imaging. According to three behavioral sub\u2010dimensions of addiction, rats were separated into two groups showing either addict\u2010like or non\u2010addict\u2010like behavior. These behavioral sub\u2010dimensions were (1) the inability to refrain from drug\u2010seeking and taking, (2) high motivation for the drug, and (3) maintained drug use despite negative consequences. In these rats, we performed structural MRI with voxel\u2010based morphometry and analyzed the interaction of GMV with behavioral sub\u2010dimensions in cocaine\u2010addicted rats. Our major findings are that GMV differentially correlate with the inability to refrain from drug\u2010seeking and taking in addict\u2010like and non\u2010addict\u2010like rats within the somatosensory cortices and the amygdala. High motivation for the drug differentially correlates with GMV in addict\u2010like and non\u2010addict\u2010like rats within the medial prefrontal cortex, and maintained drug use despite negative consequences differentially correlates with GMV in these two groups of rats within the periaqueductal gray. Our results demonstrate that the behavioral differences characterizing addict\u2010like and non\u2010addict\u2010like rats in each behavioral sub\u2010dimension of addiction are reflected by divergent covariance with GMV. We conclude that structural imaging provides specific neuroanatomical correlates of behavioral sub\u2010dimensions of addiction.<\/jats:p>","DOI":"10.1111\/adb.12500","type":"journal-article","created":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T19:34:14Z","timestamp":1487878454000},"page":"182-195","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["<i>In vivo<\/i>\n                    structural imaging in rats reveals neuroanatomical correlates of behavioral sub\u2010dimensions of cocaine addiction"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2891-8679","authenticated-orcid":false,"given":"Nazzareno","family":"Cannella","sequence":"first","affiliation":[{"name":"Institute of Psychopharmacology, Medical Faculty Mannheim Heidelberg University  Mannheim 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