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Converging evidence demonstrates functional roles of orexin signaling in arousal, sleep\/wakefulness and motivated behaviors for natural and drug rewards. Suvorexant, a dual orexin receptor antagonist, recently received approval from the US Food and Drug Administration to treat insomnia. In Experiment 1, rats self\u2010administered cocaine under a progressive\u2010ratio schedule of reinforcement and the effects of suvorexant on motivation to self\u2010administer cocaine were measured. In Experiment 2, the effects of suvorexant on cocaine reward were assessed by using a place conditioning paradigm, and 50\u2010kHz ultrasonic vocalizations were also recorded to track changes in hedonic reactivity to cocaine. To rule out potentially confounding effects of suvorexant\u2010induced somnolence, locomotor activity was also measured. In Experiment 3, the effects of suvorexant on cocaine\u2010evoked elevations in ventral striatal dopamine were examined. Data reveal that suvorexant (i) reduced the number of cocaine infusions earned during progressive\u2010ratio self\u2010administration; (ii) attenuated initial positive hedonic reactivity to cocaine and prevented cocaine place preference; (iii) did not affect cocaine\u2010induced hyperlocomotion and (iv) reduced cocaine\u2010induced elevations in extracellular ventral striatal dopamine. The present study examined the therapeutic potential of suvorexant in rodent models of cocaine use disorder. These results contribute toward a growing literature supporting therapeutic roles of orexin receptor antagonists in treating substance use disorders.<\/jats:p>","DOI":"10.1111\/adb.12507","type":"journal-article","created":{"date-parts":[[2017,4,17]],"date-time":"2017-04-17T07:42:39Z","timestamp":1492414959000},"page":"247-255","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Suvorexant, an orexin\/hypocretin receptor antagonist, attenuates motivational and hedonic properties of cocaine"],"prefix":"10.1111","volume":"23","author":[{"given":"Taylor A.","family":"Gentile","sequence":"first","affiliation":[{"name":"Center for Substance Abuse Research Lewis Katz School of Medicine, Temple University  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6982-4740","authenticated-orcid":false,"given":"Steven 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