{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:16:18Z","timestamp":1791198978072,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T00:00:00Z","timestamp":1497312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001081","name":"Hunter Medical Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001081","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>MicroRNAs (miRNAs) within the ventral and dorsal striatum have been shown to regulate addiction\u2010relevant behaviours. However, it is unclear how cocaine experience alone can alter the expression of addiction\u2010relevant miRNAs within striatal subregions. Further, it is not known whether differential expression of miRNAs in the striatum contributes to individual differences in addiction vulnerability. We first examined the effect of cocaine self\u2010administration on the expression of miR\u2010101b, miR\u2010137, miR\u2010212 and miR\u2010132 in nucleus accumbens core and nucleus accumbens shell (NAcSh), as well as dorsomedial striatum and dorsolateral striatum (DLS). We then examined the expression of these same miRNAs in striatal subregions of animals identified as being \u2018addiction\u2010prone\u2019, either immediately following self\u2010administration training or following extinction and relapse testing. Cocaine self\u2010administration was associated with changes in miRNA expression in a regionally discrete manner within the striatum, with the most marked changes occurring in the nucleus accumbens core. When we examined the miRNA profile of addiction\u2010prone rats following self\u2010administration, we observed increased levels of miR\u2010212 in the dorsomedial striatum. After extinction and relapse testing, addiction\u2010prone rats showed significant increases in the expression of miR\u2010101b, miR\u2010137, miR\u2010212 and miR\u2010132 in NAcSh, and miR\u2010137 in the DLS. This study identifies temporally specific changes in miRNA expression consistent with the engagement of distinct striatal subregions across the course of the addiction cycle. Increased dysregulation of miRNA expression in NAcSh and DLS at late stages of the addiction cycle may underlie habitual drug seeking, and may therefore aid in the identification of targets designed to treat addiction.<\/jats:p>","DOI":"10.1111\/adb.12520","type":"journal-article","created":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T04:32:41Z","timestamp":1497414761000},"page":"631-642","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Temporally specific <scp>miRNA<\/scp> expression patterns in the dorsal and ventral striatum of addiction\u2010prone rats"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1241-6145","authenticated-orcid":false,"given":"Rikki K.","family":"Quinn","sequence":"first","affiliation":[{"name":"Neurobiology of Addiction Laboratory, School of Biomedical Sciences and Pharmacy and the Centre for Translational Neuroscience and Mental Health Research University of Newcastle and the Hunter Medical Research Institute  Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9298-8607","authenticated-orcid":false,"given":"Morgan H.","family":"James","sequence":"additional","affiliation":[{"name":"Brain Health Institute Rutgers University  USA"},{"name":"Florey Institute of Neuroscience and Mental Health University of Melbourne  Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy E.","family":"Hawkins","sequence":"additional","affiliation":[{"name":"Amsterdam Brain and Cognition Center University of Amsterdam  The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda L.","family":"Brown","sequence":"additional","affiliation":[{"name":"Neurobiology of Addiction Laboratory, School of Biomedical Sciences and Pharmacy and the Centre for Translational Neuroscience and Mental Health Research University of Newcastle and the Hunter Medical 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