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Alcohol exposure during this critical period of brain maturation may affect development of PFC and frontolimbic connectivity. Adult rats exposed to adolescent intermittent ethanol (AIE; 5\u00a0g\/kg ethanol, 25 percent\n                    <jats:italic>v<\/jats:italic>\n                    \/\n                    <jats:italic>v<\/jats:italic>\n                    in water, intragastrically, 2\u2010day\u2010on, 2\u2010day\u2010off, postnatal day 25\u201354) or water control underwent resting\u2010state functional MRI to test the hypothesis that AIE induces persistent changes in frontolimbic functional connectivity under baseline and acute alcohol conditions (2\u00a0g\/kg ethanol or saline, intraperitoneally administered during scanning). Data were acquired on a Bruker 9.4\u2010T MR scanner with rats under dexmedetomidine sedation in combination with isoflurane. Frontolimbic network regions\u2010of\u2010interest for data analysis included PFC [prelimbic (PrL), infralimbic (IL), and orbitofrontal cortex (OFC) portions], nucleus accumbens (NAc), caudate putamen (CPu), dorsal hippocampus, ventral tegmental area, amygdala, and somatosensory forelimb used as a control region. AIE decreased baseline resting\u2010state connectivity between PFC subregions (PrL\u2010IL and IL\u2010OFC) and between PFC\u2010striatal regions (PrL\u2010NAc, IL\u2010CPu, IL\u2010NAc, OFC\u2010CPu, and OFC\u2010NAc). Acute ethanol induced negative blood\u2010oxygen\u2010level\u2010dependent changes within all regions of interest examined, along with significant increases in functional connectivity in control, but not AIE animals. Together, these data support the hypothesis that binge\u2010like adolescent alcohol exposure causes persistent decreases in baseline frontolimbic (particularly frontostriatal) connectivity and alters sensitivity to acute ethanol\u2010induced increases in functional connectivity in adulthood.\n                  <\/jats:p>","DOI":"10.1111\/adb.12530","type":"journal-article","created":{"date-parts":[[2017,7,9]],"date-time":"2017-07-09T23:42:47Z","timestamp":1499643767000},"page":"810-823","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Adolescent alcohol exposure decreases frontostriatal resting\u2010state functional connectivity in adulthood"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3956-145X","authenticated-orcid":false,"given":"Margaret A.","family":"Broadwater","sequence":"first","affiliation":[{"name":"Bowles Center for Alcohol Studies University of North Carolina  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