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In addition, we investigated whether minocycline can modify the effects of morphine on NAc neural activity during reinstatement of morphine\u2010seeking behavior. Minocycline increased the NAc firing activity in intact animals. Electrophysiological recording in morphine\u2010treated animals was performed, following the acquisition of morphine\u2010induced conditioned place preference (5\u00a0mg\/kg, s.c., 3\u00a0days) and a drug\u2010free extinction period. In acutely minocycline\u2010 treated animals, the neurons were recorded for 40\u00a0minutes following a single injection of either minocycline (50\u00a0\u03bcg\/5\u00a0\u03bcl, i.c.v.) or saline. Then a priming dose of morphine (1\u00a0mg\/kg, s.c.) was injected while the recording was continued for an additional 40\u00a0minutes. Minocycline significantly increased the firing rates of neurons and significantly modified morphine inhibitory effects on NAc neurons. In subchronically minocycline\u2010treated groups, the rats were given daily injections of minocycline (50\u00a0\u03bcg\/5\u00a0\u03bcl, i.c.v) during the extinction period. Then, on the reinstatement day, NAc neurons were recorded for 10\u00a0minutes, the priming dose of morphine was administered and the recording was continued for 45\u00a0minutes. Our results showed the failure of minocycline to significantly modify the inhibitory effects of morphine. In conclusion, our findings indicated that minocycline modifies morphine\u2010induced decreases in the firing rates of NAc neurons in the reinstatement phase.<\/jats:p>","DOI":"10.1111\/adb.12557","type":"journal-article","created":{"date-parts":[[2017,9,29]],"date-time":"2017-09-29T17:01:46Z","timestamp":1506704506000},"page":"1055-1066","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Minocycline increases firing rates of accumbal neurons and modifies the effects of morphine on neuronal activity"],"prefix":"10.1111","volume":"23","author":[{"given":"Reza","family":"Arezoomandan","sequence":"first","affiliation":[{"name":"Addiction Department, School of Behavioral Sciences and Mental Health (Tehran Institute of Psychiatry) Iran University of Medical Sciences Tehran 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