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Diffusion\u2010weighted magnetic resonance imaging scans were acquired from 18 patients with AUD, 15 unaffected siblings of AUD patients and 15 healthy controls. Structural networks were examined using network\u2010based statistic and connectomic analysis. Connectomic analysis showed a significant ordered difference in normalized rich club organization (AUD\u00a0&lt;\u00a0Siblings\u00a0&lt;\u00a0Controls). We also found rank ordered differences (Control\u00a0&gt;\u00a0Sibling\u00a0&gt;\u00a0AUD) for both nodal clustering coefficient and nodal local efficiency in reward system nodes, particularly left caudate, right putamen and left hippocampus. Network\u2010based statistic analyses showed that AUD group had significantly weaker connectivity than controls in the right hemisphere, mostly in the edges connecting putamen and hippocampus with other brain regions. Our results suggest that reward system network abnormalities, especially in subcortical structures, and impairments in rich\u2010club organization might be related to the familial predisposition for AUD.<\/jats:p>","DOI":"10.1111\/adb.12599","type":"journal-article","created":{"date-parts":[[2017,12,27]],"date-time":"2017-12-27T09:31:17Z","timestamp":1514367077000},"page":"265-274","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Rich club and reward network connectivity as endophenotypes for alcohol dependence: a diffusion tensor imaging study"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2340-6156","authenticated-orcid":false,"given":"Nabi","family":"Zorlu","sequence":"first","affiliation":[{"name":"Department of Psychiatry Katip Celebi University, Ataturk Training and Research Hospital  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