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The findings that reward induced by food and addictive drugs involve common mechanisms raise the possibility that gut\u2013brain hormones, which control appetite, such as amylin, could be involved in reward regulation. Amylin decreases food intake, and despite its implication in the regulation of natural rewards, tenuous evidence support amylinergic mediation of artificial rewards, such as alcohol. Therefore, the present experiments were designed to investigate the effect of salmon calcitonin (sCT), an amylin receptor agonist and analogue of endogenous amylin, on various alcohol\u2010related behaviours in rodents. We showed that acute sCT administration attenuated the established effects of alcohol on the mesolimbic dopamine system, particularly alcohol\u2010induced locomotor stimulation and accumbal dopamine release. Using the conditioned place preference model, we demonstrated that repeated sCT administration prevented the expression of alcohol's rewarding properties and that acute sCT administration blocked the reward\u2010dependent memory consolidation. In addition, sCT pre\u2010treatment attenuated alcohol intake in low alcohol\u2010consuming rats, with a more evident decrease in high alcohol consumers in the intermittent alcohol access model. Lastly, sCT did not alter peanut butter intake, blood alcohol concentration and plasma corticosterone levels in mice. Taken together, the present data support that amylin signalling is involved in the expression of alcohol reinforcement and that amylin receptor agonists could be considered for the treatment of alcohol use disorder in humans.<\/jats:p>","DOI":"10.1111\/adb.12603","type":"journal-article","created":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T00:52:50Z","timestamp":1517878370000},"page":"388-402","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Activation of amylin receptors attenuates alcohol\u2010mediated behaviours in rodents"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1359-2482","authenticated-orcid":false,"given":"Aimilia Lydia","family":"Kalafateli","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Institute of Neuroscience and Physiology The Sahlgrenska Academy at the University of Gothenburg  Gothenburg 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