{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:43:15Z","timestamp":1789684995638,"version":"4.0.1"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,5,4]],"date-time":"2018-05-04T00:00:00Z","timestamp":1525392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["DA043172"],"award-info":[{"award-number":["DA043172"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007197","name":"U.S. Public Health Service","doi-asserted-by":"publisher","award":["DA043172"],"award-info":[{"award-number":["DA043172"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Opioid use disorders are characterized in part by impairments in social functioning. Previous research indicates that laboratory rats, which are frequently used as animal models of addiction\u2010related behaviors, are capable of prosocial behavior. For example, under normal conditions, when a \u2018free\u2019 rat is placed in the vicinity of rat trapped in a plastic restrainer, the rat will release or \u2018rescue\u2019 the other rat from confinement. The present study was conducted to determine the effects of heroin on prosocial behavior in rats. For 2\u00a0weeks, rats were given the opportunity to rescue their cagemate from confinement, and the occurrence of and latency to free the confined rat was recorded. After baseline rescuing behavior was established, rats were randomly selected to self\u2010administer heroin (0.06\u00a0mg\/kg\/infusion i.v.) or sucrose pellets (orally) for 14\u00a0days. Next, rats were retested for rescuing behavior once daily for 3\u00a0days, during which they were provided with a choice between freeing the trapped cagemate and continuing to self\u2010administer their respective reinforcer. Our results indicate that rats self\u2010administering sucrose continued to rescue their cagemate, whereas heroin rats chose to self\u2010administer heroin and not rescue their cagemate. These findings suggest that rats with a history of heroin self\u2010administration show deficits in prosocial behavior, consistent with specific diagnostic criteria for opioid use disorder. Behavioral paradigms providing a choice between engaging in prosocial behavior and continuing drug use may be useful in modeling and investigating the neural basis of social functioning deficits in opioid addiction.<\/jats:p>","DOI":"10.1111\/adb.12633","type":"journal-article","created":{"date-parts":[[2018,5,4]],"date-time":"2018-05-04T07:30:18Z","timestamp":1525419018000},"page":"676-684","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Effects of heroin on rat prosocial behavior"],"prefix":"10.1111","volume":"24","author":[{"given":"Seven E.","family":"Tomek","sequence":"first","affiliation":[{"name":"Department of Psychology Arizona State University  Tempe AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela M.","family":"Stegmann","sequence":"additional","affiliation":[{"name":"Department of Psychology Arizona State University  Tempe AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2517-0351","authenticated-orcid":false,"given":"M. Foster","family":"Olive","sequence":"additional","affiliation":[{"name":"Department of Psychology Arizona State University  Tempe AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1037\/abn0000078"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471249688"},{"key":"e_1_2_6_5_1","volume-title":"Survival Analysis Using Sas: A Practice Guide","author":"Allison PD","year":"2010"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1210789"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.01385"},{"key":"e_1_2_6_8_1","first-page":"850","article-title":"Anxiolytic treatment impairs helping behavior in rats","volume":"7","author":"Ben\u2010Ami Bartal I","year":"2016","journal-title":"Front Psych"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(89)90490-5"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2017.06.004"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2012.59"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2010.10.009"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1966.tb00630.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0076258"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2017.02.002"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12415"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm655051e1"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10071-015-0872-2"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(83)90118-2"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10071-016-1052-8"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-011-2380-7"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10071-013-0692-1"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2012.00474.x"}],"container-title":["Addiction Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fadb.12633","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.12633","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/adb.12633","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.12633","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T05:19:56Z","timestamp":1724995196000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/adb.12633"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,4]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1111\/adb.12633"],"URL":"https:\/\/doi.org\/10.1111\/adb.12633","archive":["Portico"],"relation":{},"ISSN":["1355-6215","1369-1600"],"issn-type":[{"value":"1355-6215","type":"print"},{"value":"1369-1600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,4]]},"assertion":[{"value":"2017-11-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}