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We sought to understand the rapid effects of endogenous BDNF on cocaine seeking. Rats were trained to self\u2010administer cocaine and extinguished. We then microinjected two inhibitors of BDNF stimulation of tropomyosin receptor kinase B (TrkB), the non\u2010competitive receptor antagonist ANA\u201012 and TrkB\/Fc, a fusion protein that binds BDNF and prevents TrkB stimulation. Blocking TrkB or inactivating BDNF in NAcore potentiated active lever pressing, showing that endogenous BDNF tone was present and supplying inhibitory tone on cue\u2010induced reinstatement. To determine if exogenous BDNF also negatively regulated reinstatement, BDNF was microinjected into NAcore 15\u00a0minutes before cue\u2010induced reinstatement. BDNF decreased cocaine seeking through TrkB receptor binding, but had no effect on inactive lever pressing, spontaneous or cocaine\u2010induced locomotion, or on reinstated sucrose seeking. BDNF\u2010infusion potentiated within trial extinction when microinjected in the NAcore during cue\u2010 and context\u00a0+\u00a0cue induced reinstatement, and the inhibition of lever pressing lasted at least 3\u00a0days post injection. Although decreased reinstatement endured for 3\u00a0days when BDNF was administered prior to a reinstatement session, when microinjected before an extinction session or in the home cage, BDNF did not alter subsequent cued\u2010reinstatement. Together, these data show that endogenous BDNF acts on TrKB to provide inhibitory tone on reinstated cocaine seeking, and this effect was recapitulated by exogenous BDNF.<\/jats:p>","DOI":"10.1111\/adb.12638","type":"journal-article","created":{"date-parts":[[2018,6,11]],"date-time":"2018-06-11T17:30:14Z","timestamp":1528738214000},"page":"860-873","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Accumbens brain\u2010derived neurotrophic factor (BDNF) transmission inhibits cocaine seeking"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4273-1237","authenticated-orcid":false,"given":"Ana\u2010Clara","family":"Bobadilla","sequence":"first","affiliation":[{"name":"Department of Neuroscience Medical University of South Carolina  Charleston SC 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