{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T05:25:05Z","timestamp":1776749105634,"version":"3.51.2"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,8,9]],"date-time":"2018-08-09T00:00:00Z","timestamp":1533772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102017R1D1A1A02018695"],"award-info":[{"award-number":["NRF\u20102017R1D1A1A02018695"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Drug addiction is a chronic and relapsing brain disorder, influenced by complex interactions between endogenous and exogenous factors. <jats:italic>Per2<\/jats:italic>, a circadian gene, plays a role in drug addiction. Previous studies using <jats:italic>Per2<\/jats:italic>\u2010knockout mice have shown a role for <jats:italic>Per2<\/jats:italic> in cocaine, morphine and alcohol addiction. In the present study, we investigated the role of <jats:italic>Per2<\/jats:italic> in methamphetamine (METH) addiction using <jats:italic>Per2\u2010<\/jats:italic>overexpression and knockout mice. We observed locomotor sensitization responses to METH administration, and rewarding effects using a conditioned place preference test. In addition, we measured expression levels of dopamine and dopamine\u2010related genes (monoamine oxidase A, DA receptor 1, DA receptor 2, DA active transporter, tyrosine hydroxylase and cAMP response element\u2010binding protein 1) in the striatum of the mice after repeated METH treatments, using qRT\u2010PCR. <jats:italic>Per2\u2010<\/jats:italic>overexpressed mice showed decreased locomotor sensitization and rewarding effects of METH compared to the wildtype mice, whereas the opposite was observed in <jats:italic>Per2<\/jats:italic> knockout mice. Both types of transgenic mice showed altered expression levels of dopamine\u2010related genes after repeated METH administration. Specifically, we observed lower dopamine levels in <jats:italic>Per2\u2010<\/jats:italic>overexpressed mice and higher levels in <jats:italic>Per2\u2010<\/jats:italic>knockout mice. Taken together, <jats:italic>Per2<\/jats:italic> expression levels may influence the addictive effects of METH through the dopaminergic system in the striatum of mice.<\/jats:p>","DOI":"10.1111\/adb.12663","type":"journal-article","created":{"date-parts":[[2018,8,9]],"date-time":"2018-08-09T13:45:33Z","timestamp":1533822333000},"page":"946-957","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["The circadian gene, <i>Per2<\/i>, influences methamphetamine sensitization and reward through the dopaminergic system in the striatum of mice"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0524-1658","authenticated-orcid":false,"given":"Mikyung","family":"Kim","sequence":"first","affiliation":[{"name":"Uimyung Research Institute for Neuroscience, Department of Pharmacy Sahmyook University  Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raly James","family":"Custodio","sequence":"additional","affiliation":[{"name":"Uimyung Research Institute for Neuroscience, Department of Pharmacy Sahmyook University  Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chrislean Jun","family":"Botanas","sequence":"additional","affiliation":[{"name":"Uimyung Research Institute for Neuroscience, Department of Pharmacy Sahmyook University  Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9391-7595","authenticated-orcid":false,"given":"June Bryan","family":"de la Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences University of Texas Dallas  Richardson TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leandro Val","family":"Sayson","sequence":"additional","affiliation":[{"name":"Uimyung Research Institute for Neuroscience, Department of Pharmacy Sahmyook University  Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arvie","family":"Abiero","sequence":"additional","affiliation":[{"name":"Uimyung Research Institute for Neuroscience, Department of Pharmacy Sahmyook University  Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zae Young","family":"Ryoo","sequence":"additional","affiliation":[{"name":"School of Life Science, BK21 Plus KNU Creative Bio Research Group, College of Natural Sciences Kyungpook National University  Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Hoon","family":"Cheong","sequence":"additional","affiliation":[{"name":"Uimyung Research Institute for Neuroscience, Department of Pharmacy Sahmyook University  Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Uimyung Research Institute for Neuroscience, Department of Pharmacy Sahmyook University  Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.142039099"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","unstructured":"AlbrechtU BordonA SchmutzI RippergerJ(2007)The multiple facets of Per2.Cold Spring Harbor Laboratory Press72:95\u2013104","DOI":"10.1101\/sqb.2007.72.001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/074873001129001791"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00302-6"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748730403252248"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81056-9"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2016.12.017"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2013.01.014"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2005.06.005"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90225-2"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1137073"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.02067.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2000.00876.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2013.04.016"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/379606a0"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.4161\/cib.1.1.6286"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2008.04.012"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2011.03.004"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2128-10.2010"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/35094560"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(75)90233-4"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.17480\/psk.2017.61.3.188"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2017.131"},{"key":"e_1_2_7_25_1","doi-asserted-by":"crossref","unstructured":"KoobGF(1992)Dopamine addiction and reward. Paper presented at the Seminars in Neuroscience Academic Press4:139\u2013148.","DOI":"10.1016\/1044-5765(92)90012-Q"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1100\/tsw.2007.234"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.11-09-02703.1991"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.273.5275.657"},{"key":"e_1_2_7_29_1","first-page":"6","article-title":"PET imaging of dopamine D2 receptors during chronic cocaine self\u2010administration in monkeys","volume":"200","author":"Nader MA","year":"2006","journal-title":"Nature"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/35053570"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/scientificamerican0304-78"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2010.03.006"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-59427-3.00014-9"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2011.02.027"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(93)90013-P"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/30259"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1163"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2005.06.021"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.5.896"},{"key":"e_1_2_7_40_1","volume-title":"World drug report","author":"United Nations Office on Drugs and Crime","year":"2016"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.890140210"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/386830a0"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1996.tb05936.x"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1544-06.2006"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/22118"}],"container-title":["Addiction Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fadb.12663","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.12663","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T02:02:14Z","timestamp":1694311334000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/adb.12663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,9]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1111\/adb.12663"],"URL":"https:\/\/doi.org\/10.1111\/adb.12663","archive":["Portico"],"relation":{},"ISSN":["1355-6215","1369-1600"],"issn-type":[{"value":"1355-6215","type":"print"},{"value":"1369-1600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,9]]},"assertion":[{"value":"2018-02-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}