{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T19:52:00Z","timestamp":1759693920275,"version":"3.37.3"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T00:00:00Z","timestamp":1539734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["DA030540","DA034877"],"award-info":[{"award-number":["DA030540","DA034877"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Illicit drug use among aging cohorts is increasing, yet little is known about functional impairments in older drug users. Given the importance of social integration for aging and documented social decrements in cocaine users, we examined social function and its neurocognitive substrates in aging cocaine users relative to carefully matched non\u2010cocaine users. Regular (\u2265twice\/week), long\u2010term (\u226515\u00a0years) cocaine smokers 50\u201360\u00a0years old (COCs; <jats:italic>n<\/jats:italic>\u00a0=\u00a022; four women) and controls (CTRLs; <jats:italic>n<\/jats:italic>\u00a0=\u00a019; four women) underwent standardized probes of social reward and threat processing during functional magnetic resonance imaging and a behavioral facial affect recognition task. Self\u2010report and peer\u2010report of daily interpersonal function were also collected. COCs, and CTRLs reporting current marijuana or alcohol use, were tested after four drug\u2010free inpatient days. COCs had pronounced problems in daily social function relative to CTRLs indicated by both their own and their peers' reports. Compared with CTRLs, COCs had stronger amygdala responses to social threat versus control stimuli, with no other differences in social processing or cognition. Aging cocaine users appear to have marked, generalized difficulties in \u2018real\u2010world\u2019 interpersonal function but largely intact social processing on laboratory\u2010based measures when compared with appropriately matched controls and tested under well\u2010controlled conditions. Daily social difficulties may be related to transient factors such as acute\/residual drug effects or cocaine\u2010related changes in health behaviors (e.g. disrupted sleep and poor diet). These data suggest that interpersonal function may be a valid intervention target for aging cocaine users and warrants further study in older drug users.<\/jats:p>","DOI":"10.1111\/adb.12669","type":"journal-article","created":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T10:45:04Z","timestamp":1539773104000},"page":"1044-1055","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Social motivational processing and interpersonal function in aging cocaine smokers"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6718-0099","authenticated-orcid":false,"given":"Gillinder","family":"Bedi","sequence":"first","affiliation":[{"name":"Department of Psychiatry Columbia University Medical Center and New York State Psychiatric Institute  New York NY USA"},{"name":"Centre for Youth Mental Health University of Melbourne  Australia"},{"name":"Orygen, National Centre of Excellence in Youth 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USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nehal P.","family":"Vadhan","sequence":"additional","affiliation":[{"name":"Hofstra\u2010Northwell School of Medicine and Feinstein Institute for Medical Research  Great Neck NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie","family":"Marino","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Columbia University Medical Center and New York State Psychiatric Institute  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1220-9528","authenticated-orcid":false,"given":"Margaret","family":"Haney","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Columbia University Medical Center and New York State Psychiatric Institute  New York NY 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