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Previously, we found that exogenous orexin via OX\n                    <jats:sub>1<\/jats:sub>\n                    and OX\n                    <jats:sub>2<\/jats:sub>\n                    receptors can impair low frequency stimulation\u2010induced depotentiation, i.e. restoring potentiation of excitatory synaptic transmission (re\u2010potentiation) in mouse hippocampal slices. Here, we found this re\u2010potentiation in hippocampal slices from mice that had acquired conditioned place preference (CPP) to cocaine. Both 10 and 20\u00a0mg\/kg of cocaine induced similar magnitudes of CPP in mice and re\u2010potentiation in their hippocampal slices, but differed in their susceptibility to TCS1102, a dual (OX\n                    <jats:sub>1<\/jats:sub>\n                    and OX\n                    <jats:sub>2<\/jats:sub>\n                    ) orexin receptor antagonist. TCS1102 significantly attenuated CPP and hippocampal re\u2010potentiation induced by cocaine at 10\u00a0mg\/kg but not at 20\u00a0mg\/kg. Nonetheless, SCH23390, an antagonist of dopamine D1\u2010like receptors (D1\u2010likeRs), inhibited the effects induced by both doses of cocaine. SKF38393, a D1\u2010likeR\u2010selective agonist, also induced hippocampal re\u2010potentiation\n                    <jats:italic>in vitro<\/jats:italic>\n                    . Interestingly, this effect was attenuated by TCS1102. Conversely, SCH23390 prevented orexin A\u2010induced hippocampal re\u2010potentiation. These results suggest that endogenous orexins are released in mice during cocaine\u2010CPP acquisition, which sustains potentiated hippocampal transmission via OX\n                    <jats:sub>1<\/jats:sub>\n                    \/OX\n                    <jats:sub>2<\/jats:sub>\n                    receptors and may contribute to the addiction memory of cocaine. This effect of endogenous orexins, however, may be substituted by dopamine that may dominate hippocampal re\u2010potentiation and CPP via D1\u2010likeRs when the reinforcing effect of cocaine is high.\n                  <\/jats:p>","DOI":"10.1111\/adb.12672","type":"journal-article","created":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T20:01:32Z","timestamp":1538424092000},"page":"1153-1166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Orexin\u2010mediated restoration of hippocampal synaptic potentiation in mice with established cocaine\u2010conditioned place preference"],"prefix":"10.1111","volume":"24","author":[{"given":"Guan\u2010Ling","family":"Lu","sequence":"first","affiliation":[{"name":"Graduate Institute of Pharmacology College of Medicine, National Taiwan University Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming Tatt","family":"Lee","sequence":"additional","affiliation":[{"name":"Graduate Institute of Pharmacology College of Medicine, National Taiwan University Taiwan"},{"name":"Graduate Institute of Brain and Mind Sciences College of Medicine, National Taiwan University Taiwan"},{"name":"Faculty of Pharmaceutical Sciences UCSI University Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5356-940X","authenticated-orcid":false,"given":"Lih\u2010Chu","family":"Chiou","sequence":"additional","affiliation":[{"name":"Graduate Institute of Pharmacology College of Medicine, National Taiwan University Taiwan"},{"name":"Graduate Institute of Brain and Mind Sciences College of Medicine, National Taiwan University Taiwan"},{"name":"Graduate Institute of Acupuncture Science China Medical University 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