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The dorsal raphe nucleus, where 5\u2010HT neurons originate, and the Hb are anatomically and reciprocally interconnected. Evidence exists that 5\u2010HT influences Hb glutamatergic transmission. Using serotonin transporter knockout (SERT<jats:sup>\u2212\/\u2212<\/jats:sup>) rats, which show depression\u2010like behavior and increased cocaine intake, we investigated the effect of SERT reduction on expression of genes involved in glutamate neurotransmission under both baseline conditions as well as after short\u2010access or long\u2010access cocaine (ShA and LgA, respectively) intake. In cocaine\u2010na\u00efve animals, SERT removal led to reduced baseline Hb mRNA levels of critical determinants of glutamate transmission, such as <jats:italic>SLC1A2<\/jats:italic>, the main glutamate transporter and N\u2010methyl\u2010D\u2010aspartate (<jats:italic>Grin1<\/jats:italic>, <jats:italic>Grin2A<\/jats:italic> and <jats:italic>Grin2B<\/jats:italic>) as well as \u03b1\u2010amino\u20103\u2010hydroxy\u20105\u2010methyl\u20104\u2010isoxazolepropionic acid (<jats:italic>Gria1<\/jats:italic> and <jats:italic>Gria2<\/jats:italic>) receptor subunits, with no changes in the scaffolding protein <jats:italic>Dlg4<\/jats:italic>. In response to ShA and LgA cocaine intake, <jats:italic>SLC1A2<\/jats:italic> and <jats:italic>Grin1<\/jats:italic> mRNA levels decreased in SERT<jats:sup>+\/+<\/jats:sup> rats to levels equal of those of SERT<jats:sup>\u2212\/\u2212<\/jats:sup> rats. Our data reveal that increased extracellular levels of 5\u2010HT modulate glutamate neurotransmission in the Hb, serving as critical neurobiological substrate for vulnerability to cocaine addiction.<\/jats:p>","DOI":"10.1111\/adb.12673","type":"journal-article","created":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T10:31:44Z","timestamp":1535106704000},"page":"1167-1178","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Increased cocaine self\u2010administration in rats lacking the serotonin transporter: a role for glutamatergic signaling in the habenula"],"prefix":"10.1111","volume":"24","author":[{"given":"Lucia","family":"Caffino","sequence":"first","affiliation":[{"name":"Department of Pharmacological and Biomolecular Sciences Universit\u00e0 degli Studi di Milano  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel 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