{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:40:27Z","timestamp":1791499227507,"version":"4.3.4"},"reference-count":53,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T00:00:00Z","timestamp":1537228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Although the involvement of dopamine in gambling disorder (GD) has long been hypothesized, its precise role remains unclear. The action of dopamine in the synapses is regulated by the dopamine transporter (DAT). We hereinafter present significant differences between a sample of 15 treatment\u2010seeking GD subjects and 17 healthy controls in terms of striatal DAT availability, and we explore its association with reward\u2010based decision making. We performed\n                      <jats:sup>123<\/jats:sup>\n                      I\u2010FP\u2010CIT Single\u2010photon emission computed tomography (SPECT) and correlated DAT binding ratios in the bilateral caudate and putamen with gambling symptoms (G\u2010SAS, PG\u2010YBOCS) and behaviors, as well as other psychometric variables (anhedonia and impulsivity). Gambling disorder (GD) subjects were also administered a computerized version of the Iowa gambling task (IGT) to assess reward\u2010based decision making. We found reduced DAT availability in GD subjects compared with healthy controls (\u221213.30% in right caudate, \u221211.11% in right putamen, \u221211.44% in left caudate, and \u221211.46% in the left putamen). We also found that striatal DAT availability was inversely correlated with days spent gambling and IGT performance in GD subjects. These results provide evidence for a presynaptic dopaminergic dysfunction in striatal regions of GD subjects. Functional DAT down\u2010regulation possibly sustains the transition towards compulsive gambling addiction, characterized both by hyperdopaminergic and hypodopaminergic states in the context of a sensitized dopaminergic system.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/adb.12677","type":"journal-article","created":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T06:35:12Z","timestamp":1537252512000},"page":"1077-1086","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Striatal presynaptic dopaminergic dysfunction in gambling disorder: A\n                    <scp>\n                      <sup>123<\/sup>\n                      I\u2010FP\u2010CIT SPECT\n                    <\/scp>\n                    study"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4164-3040","authenticated-orcid":false,"given":"Mauro","family":"Pettorruso","sequence":"first","affiliation":[{"name":"Institute of Psychiatry and Psychology Fondazione Policlinico Universitario \u201cA. Gemelli\u201d Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Martinotti","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Imaging and Clinical Science, \u201cG. d'Annunzio\u201d University of Chieti, Italy; Department of Pharmacy, Pharmacology and Clinical Science University of Hertfordshire  Herts UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Cocciolillo","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Medicine Fondazione Policlinico Universitario \u201cA. Gemelli\u201d Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"De Risio","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry and Psychology Fondazione Policlinico Universitario \u201cA. Gemelli\u201d Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annarita","family":"Cinquino","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Medicine Fondazione Policlinico Universitario \u201cA. Gemelli\u201d Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Di Nicola","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry and Psychology Fondazione Policlinico Universitario \u201cA. Gemelli\u201d Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Camardese","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry and Psychology Fondazione Policlinico Universitario \u201cA. 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