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Previous work shows that a single dose of cocaine reduced the AMPA\u2010to\u2010NMDA ratio in <jats:italic>Asic1a<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup> mice, an effect observed after withdrawal in wild\u2010type mice, whereas ASIC1A overexpression in the NAcore of rats decreases cocaine self\u2010administration. However, whether ASIC1A overexpression in the NAcore alters measures of drug\u2010seeking behavior after the self\u2010administration period is unknown. To examine this issue, the ASIC1A subunit was overexpressed in male Sprague\u2010Dawley rats by injecting them with adeno\u2010associated virus, targeted at the NAcore, after completion of 2\u00a0weeks of cocaine or food self\u2010administration. After 21\u00a0days of homecage abstinence, rats underwent a cue\u2010\/context\u2010driven drug\/food\u2010seeking test, followed by extinction training and then drug\/food\u2010primed, cued, and cued\u00a0+\u00a0drug\/food\u2010primed reinstatement tests. The results indicate that ASIC1A overexpression in the NAcore enhanced cue\u2010\/context\u2010driven cocaine seeking, cocaine\u2010primed reinstatement, and cued\u00a0+\u00a0cocaine\u2010primed reinstatement but had no effect on food\u2010seeking behavior, indicating a selective effect for ASIC1A in the processes underlying extinction and cocaine\u2010seeking behavior.<\/jats:p>","DOI":"10.1111\/adb.12690","type":"journal-article","created":{"date-parts":[[2018,11,6]],"date-time":"2018-11-06T09:44:57Z","timestamp":1541497497000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Overexpression of ASIC1A in the nucleus accumbens of rats potentiates cocaine\u2010seeking behavior"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8691-1184","authenticated-orcid":false,"given":"Andrea L.","family":"Gutman","sequence":"first","affiliation":[{"name":"Department of Psychological and Brain 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