{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T22:18:18Z","timestamp":1789856298009,"version":"4.0.1"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T00:00:00Z","timestamp":1542931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01GQ1003B"],"award-info":[{"award-number":["01GQ1003B"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01ZX1311A"],"award-info":[{"award-number":["01ZX1311A"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["No 668863 (SyBil\u2010AA)"],"award-info":[{"award-number":["No 668863 (SyBil\u2010AA)"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 636\/D6"],"award-info":[{"award-number":["SFB 636\/D6"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Frontostriatal circuits are centrally involved in the selection of behavioral programs and play a prominent role in alcohol use disorder (AUD) as well as other mental disorders. However, how frontal regions change their striatal connectivity to implement adaptive cognitive control is still not fully understood. Here, we developed an approach for functional magnetic resonance imaging (fMRI) connectivity analysis in which we change the focus from connectivity to individual voxels towards spatial information about the location of strongest functional connectivity. In resting state data of <jats:italic>n<\/jats:italic>\u00a0=\u00a066 participants with AUD and <jats:italic>n<\/jats:italic>\u00a0=\u00a040 healthy controls (HC) we used the approach to estimate frontostriatal connectivity gradients consistent with nonhuman primate tract\u2010tracing studies, characterized for each frontal voxel the striatal peak connectivity location on this gradient (PeaCoG), and tested for group differences and associations with clinical variables. We identified a cluster in the right orbitofrontal cortex (rOFC) with a peak connectivity shift towards ventral striatal regions in AUD. Reduced variability of rOFC striatal peak connectivity in the AUD group suggests a \u201cclamping\u201d to the ventral striatum as the underlying effect. Within the AUD group striatal peak connectivity in the superior frontal gyrus was associated with self\u2010efficacy to abstain from alcohol, in the medial frontal and dorsolateral prefrontal cortex with alcohol dependency, and in the right inferior frontal gyrus with the urge to consume alcohol. Our results demonstrate that the functional topography of frontostriatal circuits exhibits interindividual variability, which provides insight into frontostriatal network adaptations in AUD and potentially other mental disorders.<\/jats:p>","DOI":"10.1111\/adb.12692","type":"journal-article","created":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T12:19:17Z","timestamp":1542975557000},"page":"1245-1253","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Shifts in the functional topography of frontal cortex\u2010striatum connectivity in alcohol use disorder"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3071-5296","authenticated-orcid":false,"given":"Martin Fungisai","family":"Gerchen","sequence":"first","affiliation":[{"name":"Department of Clinical Psychology Central Institute of Mental Health, University of Heidelberg\/Medical Faculty Mannheim  Mannheim Germany"},{"name":"Bernstein Center for Computational Neuroscience Heidelberg\/Mannheim  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alena","family":"Rentsch","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology Central Institute of Mental Health, University of Heidelberg\/Medical Faculty Mannheim  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Kirsch","sequence":"additional","affiliation":[{"name":"Department of Addiction Behavior and Addiction Medicine, Central Institute of Mental Health University of Heidelberg\/Medical Faculty Mannheim  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7213-0398","authenticated-orcid":false,"given":"Falk","family":"Kiefer","sequence":"additional","affiliation":[{"name":"Department of Addiction Behavior and Addiction Medicine, Central Institute of Mental Health University of Heidelberg\/Medical Faculty Mannheim  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0817-1248","authenticated-orcid":false,"given":"Peter","family":"Kirsch","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology Central Institute of Mental Health, University of Heidelberg\/Medical Faculty Mannheim  Mannheim Germany"},{"name":"Bernstein Center for Computational Neuroscience Heidelberg\/Mannheim  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2003.10.003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2016.18.1\/shaber"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-016-1250-9"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094640"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3119"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2007.00453.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2004.04.002"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.10.1642"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2008.00891.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12037"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhu134"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12272"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs190"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-psych-122414-033457"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2010.03022.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00270.2012"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhn041"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1486-08.2008"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0228-14.2014"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.12.010"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00995.2011"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5806-12.2014"},{"key":"e_1_2_8_24_1","first-page":"18","article-title":"Identifying basal ganglia divisions in individuals using resting\u2010state functional connectivity MRI","volume":"4","author":"Barnes KA","year":"2010","journal-title":"Front Syst Neurosci"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2636-14.2015"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0106768"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.05-03-00776.1985"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(78)90059-8"},{"key":"e_1_2_8_29_1","volume-title":"Structured Clinical Interview for DSM\u2010IV Axis I Disorders: Patient Edition (February 1996 Final), SCID\u2010I\/P","author":"First MB","year":"1998"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.95.8s2.9.x"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsa.1994.55.141"},{"key":"e_1_2_8_32_1","volume-title":"Alcohol Dependence Scale (ADS) User's Guide","author":"Skinner HA","year":"1984"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1995.tb01554.x"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-017-0805-y"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12352"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20729"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.01.060"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.03.061"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1974.10482955"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.3102\/10769986012001045"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/10.3.318"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5587-09.2010"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.12.109"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2013.12.003"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2006.07.002"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1511480"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2015.01.004"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/desc.12448"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2015.00356"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-018-1604-3"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12278"}],"container-title":["Addiction Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fadb.12692","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.12692","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/adb.12692","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.12692","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T21:55:03Z","timestamp":1694210103000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/adb.12692"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,23]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1111\/adb.12692"],"URL":"https:\/\/doi.org\/10.1111\/adb.12692","archive":["Portico"],"relation":{},"ISSN":["1355-6215","1369-1600"],"issn-type":[{"value":"1355-6215","type":"print"},{"value":"1369-1600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,23]]},"assertion":[{"value":"2018-06-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}