{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:53:24Z","timestamp":1787237604049,"version":"build-2736575974"},"reference-count":68,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T00:00:00Z","timestamp":1546905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003529","name":"European Union Agency for Network and Information Security","doi-asserted-by":"publisher","award":["JUST\/2013\/DPIP\/AG\/4823\u2010EU MADNESS"],"award-info":[{"award-number":["JUST\/2013\/DPIP\/AG\/4823\u2010EU MADNESS"]}],"id":[{"id":"10.13039\/501100003529","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005367","name":"Universidad Nacional de Educaci\u00f3n a Distancia","doi-asserted-by":"publisher","award":["Plan de Promoci\u00f3n de la Investigaci\u00f3n"],"award-info":[{"award-number":["Plan de Promoci\u00f3n de la Investigaci\u00f3n"]}],"id":[{"id":"10.13039\/501100005367","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Relapse into drug use is a major problem faced by recovering addicts. In humans, an intensification of the desire for the drug induced by environmental cues\u2014incubation of drug craving\u2014has been observed. In rodents, this phenomenon has been modeled by studying drug seeking under extinction after different times of drug withdrawal (or using a natural reinforcer). Although much progress has been made, an integrated approach simultaneously studying different drug classes and natural reward and examining different brain regions is lacking. Lewis rats were used to study the effects of cocaine, heroin, and sucrose seeking incubation on six key brain regions: the nucleus accumbens shell\/core, central\/basolateral amygdala, and dorsomedial\/ventromedial prefrontal cortex. We analyzed PSD95 and gephyrin protein levels, gene expression of glutamatergic, GABAergic and endocannabinoid elements, and amino acid transmitter levels. The relationships between the areas studied were examined by Structural Equation Modelling. Pathways from medial prefrontal cortex and basolateral complex of the amygdala to central nucleus of the amygdala, but not to the nucleus accumbens, were identified as common elements involved in the incubation phenomenon for different substances. These results suggest a key role for the central nucleus of amygdala and its cortical and amygdalar afferences in the incubation phenomenon, and we suggest that by virtue of its regulatory effects on glutamatergic and GABAergic dynamics within amygdalar circuits, the endocannabinoid system might be a potential target to develop medications that are effective in the context of relapse.<\/jats:p>","DOI":"10.1111\/adb.12706","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T02:31:23Z","timestamp":1547001083000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Central nucleus of the amygdala as a common substrate of the incubation of drug and natural reinforcer seeking"],"prefix":"10.1111","volume":"25","author":[{"given":"David","family":"Roura\u2010Mart\u00ednez","sequence":"first","affiliation":[{"name":"Department of Psychobiology School of Psychology, UNED  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos","family":"Ucha","sequence":"additional","affiliation":[{"name":"Department of Psychobiology School of Psychology, UNED  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Orihuel","sequence":"additional","affiliation":[{"name":"Department of Psychobiology School of Psychology, UNED  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"Ballesteros\u2010Y\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"School of Medicine University of Castilla La Mancha  Ciudad Real Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6313-5485","authenticated-orcid":false,"given":"Carlos Alberto","family":"Castillo","sequence":"additional","affiliation":[{"name":"School of Occupational Therapy Speech Therapy and Nursing, University of Castilla\u2010La Mancha  Talavera de la Reina Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Marcos","sequence":"additional","affiliation":[{"name":"Department of Psychobiology School of Psychology, UNED  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Ambrosio","sequence":"additional","affiliation":[{"name":"Department of Psychobiology School of Psychology, UNED  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3438-9387","authenticated-orcid":false,"given":"Alejandro","family":"Higuera\u2010Matas","sequence":"additional","affiliation":[{"name":"Department of Psychobiology School of Psychology, UNED  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.07.014"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068791"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2016.2181"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12140"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12205"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2011.06.001"},{"key":"e_1_2_8_8_1","first-page":"25","article-title":"Animal models of drug relapse and craving","volume":"224","author":"Venniro M","year":"2016","journal-title":"From drug priming\u2010induced reinstatement to incubation of craving after voluntary abstinence. Prog Brain Res"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2016.39"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2010.00281.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1914-12.2012"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3027-08.2008"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-012-2784-z"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2015.02.048"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2016.287"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.12.019"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3533"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2016.10.003"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.08.023"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1524739113"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12430"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.09.024"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1821-17.2017"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2017.08.018"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.02.018"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.09.020"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1712-16.2016"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0671-04.2004"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-12-04815.2003"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1251"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0350-11.2011"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06995"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-009-1755-5"},{"key":"e_1_2_8_34_1","volume-title":"The rat brain in stereotaxic coordinates","author":"Paxinos G","year":"2007"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087293"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(87)90021-2"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/29.9.e45"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp045"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2012.03.017"},{"key":"e_1_2_8_40_1","volume-title":"Discovering statistics using IBM SPSS statistics","author":"Filed A","year":"2013"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4607-07.2008"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20233"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/neuro.02.004.2008"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2007.05014.x"},{"key":"e_1_2_8_45_1","article-title":"Deficient endocannabinoid signaling in the central amygdala contributes to alcohol dependence\u2010related anxiety\u2010like behavior and excessive alcohol intake","volume":"5","author":"Serrano A","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.02.034"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1383"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.04.011"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2014.320"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2007.04.019"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1505-16.2016"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07167"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.12.030"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt036"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2008.04.022"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2017.09.025"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03033814"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3091-16.2016"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-011-2210-y"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.155"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.02.052"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3082-12.2013"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3590"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3291-17.2018"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2017.57"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-013-3294-3"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3667-06.2007"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20486"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2016.04.003"}],"container-title":["Addiction Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fadb.12706","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.12706","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/adb.12706","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.12706","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T07:41:22Z","timestamp":1694072482000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/adb.12706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,8]]},"references-count":68,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1111\/adb.12706"],"URL":"https:\/\/doi.org\/10.1111\/adb.12706","archive":["Portico"],"relation":{},"ISSN":["1355-6215","1369-1600"],"issn-type":[{"value":"1355-6215","type":"print"},{"value":"1369-1600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,8]]},"assertion":[{"value":"2018-05-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12706"}}