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In this study, we investigated in pregnant women the association between urine ethylglucuronide (EtG\u2014a biomarker of alcohol drinking) and indicators of the physical characteristics of FASD by prenatal ultrasound in the second trimester of gestation. We also correlated these data with the AUDIT\u2010C, T\u2010ACE\/TACER\u20103, TWEAK, and food habit diary, screening questionnaires used to disclose alcohol drinking during pregnancy. Forty\u2010four pregnant women were randomly enrolled and examined for ultrasound investigation during the second trimester of gestation. Urine samples were provided by pregnant women immediately after the routine interviews. EtG determinations were performed with a cutoff established at 100\u00a0ng\/mL, a value indicating occasional alcohol drinking. Fifteen of the enrolled pregnant women overcame the EtG cutoff (34.09%). Analysis of variance (ANOVA) revealed that the fetuses of the positive EtG pregnant women had significantly longer interorbital distance and also significantly increased frontothalamic distance (<jats:italic>P<\/jats:italic>'s\u00a0&lt;\u00a00.02). Quite interestingly, no direct correlation was found between EtG data and both food diary and AUDIT\u2010C. However, a significant correlation was observed between urinary EtG and T\u2010ACE (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.375; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.012) and between urinary EtG and TWEAK (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.512; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and a concordance with all questionnaire for EtG values higher than 500\u00a0ng\/mL. This study provides clinical evidence that the diagnosis of maternal alcohol consumption during pregnancy by urine EtG may disclose FASD\u2010related damage in the fetus.<\/jats:p>","DOI":"10.1111\/adb.12724","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T16:13:34Z","timestamp":1551284014000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Fetus morphology changes by second\u2010trimester ultrasound in pregnant women drinking alcohol"],"prefix":"10.1111","volume":"25","author":[{"given":"Giampiero","family":"Ferraguti","sequence":"first","affiliation":[{"name":"Department of Experimental Medicine Sapienza University Hospital of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Merlino","sequence":"additional","affiliation":[{"name":"Department of Gynecological\u2010Obstetric Sciences and Urological Sciences Sapienza University 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