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Few studies have documented the effects of a history of adolescent binge drinking on neurophysiological consequences in young adulthood. Synchrony of phase (phase locking (PL)) of event\u2010related oscillations (EROs) within and between different brain areas reflects communication exchange between neural networks and is a sensitive measure of adolescent development in both rats and humans, and thus may be a good translational measure of the potential harmful effects of alcohol exposure during adolescence. In this study, EROs were collected from 1041 young adults of Mexican American and American Indian ancestry (age 18\u201030\u00a0years) with and without a history of adolescent binge drinking (five drinks for boys and four for girls per occasion at least once per month) and in 74 young adult rats with and without a history of 5\u00a0weeks of adolescent alcohol vapor exposure. PL of theta and beta frequencies between frontal and parietal cortex were estimated using an auditory\u2010oddball paradigm in the rats and a visual facial expression paradigm in the humans. Significantly lower PL between frontal and parietal cortices in the theta frequencies was seen in both the humans and the rats with a history of adolescent alcohol exposure as compared with their controls. These findings suggest that alcohol exposure during adolescence may result in decreases in synchrony between cortical neuronal networks, suggesting a developmental delay, in young adult humans and in rats.<\/jats:p>","DOI":"10.1111\/adb.12732","type":"journal-article","created":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T22:12:31Z","timestamp":1552947151000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Phase locking of event\u2010related oscillations is decreased in both young adult humans and rats with a history of adolescent alcohol exposure"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2717-994X","authenticated-orcid":false,"given":"Cindy L.","family":"Ehlers","sequence":"first","affiliation":[{"name":"Department of Neuroscience The Scripps Research Institute  La Jolla CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evie","family":"Phillips","sequence":"additional","affiliation":[{"name":"Department of Neuroscience The Scripps Research Institute  La Jolla CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek","family":"Wills","sequence":"additional","affiliation":[{"name":"Department of Neuroscience The Scripps Research Institute  La Jolla CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Benedict","sequence":"additional","affiliation":[{"name":"Department of Neuroscience The Scripps Research Institute  La Jolla CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Sanchez\u2010Alavez","sequence":"additional","affiliation":[{"name":"Department of Neuroscience The Scripps Research Institute  La Jolla CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,18]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Monitoring the Future National Results on Adolescent Drug Use: Overview of Key Findings, 2008. 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