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Previous studies have reported that cocaine\u2010induced autophagy is involved in neuroinflammation and cell death. However, the role of autophagy in psychomotor sensitivity to cocaine has not been explored. Here, we reported that D<jats:sub>1<\/jats:sub> receptor \u2010CaMKII\u2010AMPK\u2010FoxO3a signaling pathway was involved in acute cocaine application\u2010induced autophagy in the nucleus accumbens (NAc) both <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>. Furthermore, we found that knockdown of the ATG5 gene in the NAc augmented behavioral response to cocaine, and induction of autophagy in the NAc with rapamycin attenuated cocaine\u2010induced behavioral response, which was coincident with the alterations of dendritic spine density in neurons of NAc. These results suggest that cocaine exposure leads to the induction of autophagy, which is a protective mechanism against behavioral response to cocaine of male mice.<\/jats:p>","DOI":"10.1111\/adb.12736","type":"journal-article","created":{"date-parts":[[2019,2,21]],"date-time":"2019-02-21T03:22:07Z","timestamp":1550719327000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Activation of AMPK\u2010dependent autophagy in the nucleus accumbens opposes cocaine\u2010induced behaviors of mice"],"prefix":"10.1111","volume":"25","author":[{"given":"Hai\u2010Feng","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Basic Medicine, Tongji Medical College Huazhong University of Science and Technology  Wuhan 430030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, 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