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High mobility group box 1 (HMGB1) is one kind of inflammatory molecules that is expressed both on neurons and immune cells. Previous studies of HMGB1 in the CNS have largely focused on immune function, and the role of HMGB1 in neurons and cocaine addiction remains unknown. Here, we show that cocaine exposure induced the translocation and release of HMGB1 in the nucleus accumbens (NAc) neurons. Gain and loss of HMGB1 in the NAc bidirectionally regulate cocaine\u2010induced conditioned place preference. From the nucleus to the cytosol, HMGB1 binds to glutamate receptor subunits (GluA2\/GluN2B) on the membrane, which regulates cocaine\u2010induced synaptic adaptation and the formation of cocaine\u2010related memory. These data unveil the role of HMGB1 in neurons and provide the evidence for the HMGB1 involvement in drug addiction.<\/jats:p>","DOI":"10.1111\/adb.12739","type":"journal-article","created":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T19:21:19Z","timestamp":1557170479000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Neuronal <scp>HMGB1<\/scp> in nucleus accumbens regulates cocaine reward memory"],"prefix":"10.1111","volume":"25","author":[{"given":"Shuang\u2010Qi","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Basic Medicine, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medicine, Tongji Medical College Huazhong University of Science and 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