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The mechanisms of action of naltrexone are thought to involve attenuation of the hedonic effects of alcohol and potentiation of its aversive effects. In order to provide a quantitative estimate of the effects of naltrexone on subjective response to alcohol, the aims of this meta\u2010analytic review are to examine the effects of naltrexone across four domains of subjective response. Meta\u2010analyses of naltrexone effects on alcohol craving (<jats:italic>k<\/jats:italic>\u00a0=\u00a016, N\u00a0=\u00a0686), stimulation (<jats:italic>k<\/jats:italic>\u00a0=\u00a015, N\u00a0=\u00a0675), sedation (<jats:italic>k<\/jats:italic>\u00a0=\u00a018, N\u00a0=\u00a0777), and negative mood (<jats:italic>k<\/jats:italic>\u00a0=\u00a09, N\u00a0=\u00a0281) suggested that under laboratory conditions and compared with placebo, naltrexone reduces craving (Hedges <jats:italic>g<\/jats:italic>\u00a0=\u00a0\u22120.252; SE\u00a0=\u00a00.054; 95% CI, \u22120.375 to \u22120.130; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), reduces stimulation (<jats:italic>g<\/jats:italic>\u00a0=\u00a0\u22120.223; SE\u00a0=\u00a00.067; 95% CI, \u22120.372 to \u22120.074; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), increases sedation (<jats:italic>g<\/jats:italic>\u00a0=\u00a00.251; SE\u00a0=\u00a00.064; 95% CI, 0.112\u20100.389; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), and increases negative mood (<jats:italic>g<\/jats:italic>\u00a0=\u00a00.227; SE\u00a0=\u00a00.047; 95% CI, 0.100\u20100.354; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). Results were robust when drinks per month and alcohol dose were added to the models as covariates. The effects of naltrexone varied by severity of alcohol use with medication effects on craving and stimulation being observed in sample of both heavy drinkers and AUD individuals. These results are consistent with the hypothesized mechanisms of action of NTX, although the effects are of small magnitude. This meta\u2010analysis aggregates across multiple human laboratory studies of NTX's effects on subjective response to alcohol, providing a comprehensive summary of a key mechanism of NTX efficacy, namely, alteration of the subjective experience of alcohol.<\/jats:p>","DOI":"10.1111\/adb.12747","type":"journal-article","created":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T03:53:58Z","timestamp":1559274838000},"page":"1138-1152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Naltrexone effects on subjective responses to alcohol in the human laboratory: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5734-9444","authenticated-orcid":false,"given":"Lara A.","family":"Ray","sequence":"first","affiliation":[{"name":"Department of Psychology University of California, Los Angeles  Los Angeles CA USA"},{"name":"Department of Psychiatry and Biobehavioral Sciences University of California, Los Angeles  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ReJoyce","family":"Green","sequence":"additional","affiliation":[{"name":"Department of Psychology University of California, Los Angeles  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.O.","family":"Roche","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Maryland  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly","family":"Magill","sequence":"additional","affiliation":[{"name":"Center for Alcohol and Addiction Studies Brown University  Providence RI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spencer","family":"Bujarski","sequence":"additional","affiliation":[{"name":"Department of Psychology University of California, Los Angeles  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2015.0584"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/08897077.2015.1133472"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2190\/PM.42.3.b"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60746-7"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.17.2003"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.12875"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1992.01820110045007"},{"key":"e_1_2_8_9_1","doi-asserted-by":"crossref","unstructured":"RosnerS Hackl\u2010HerrwerthA LeuchtS VecchiS SrisurapanontM SoykaM(2010)Opioid antagonists for alcohol dependence. 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