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While prescription opioid analgesics are essential for treating acute pain, cessation of use in individuals with a physical dependence induces an aversive withdrawal syndrome that promotes continued drug use to alleviate\/avoid these symptoms. Additionally, repeated bouts of withdrawal often lead to an increased propensity for relapse. Understanding the neurobiology underlying withdrawal is essential for providing novel treatment options to alleviate physiological and affective components accompanying the cessation of opiate use. Here, we administered morphine and precipitated withdrawal with naloxone to investigate behavioral and cellular responses in C57BL\/6J male and female mice. Following 3\u00a0days of administration, both male and female mice demonstrated sensitized withdrawal symptoms. Since the bed nucleus of the stria terminalis (BNST) plays a role in mediating withdrawal\u2010associated behaviors, we examined plastic changes in inhibitory synaptic transmission within this structure 24\u00a0hours following the final precipitated withdrawal. In male mice, morphine withdrawal increased spontaneous GABAergic signaling compared with controls. In contrast, morphine withdrawal decreased spontaneous GABAergic signaling in female mice. Intriguingly, these opposing GABAergic effects were contingent upon activity\u2010dependent dynamics within the ex vivo slice. Our findings suggest that male and female mice exhibit some divergent cellular responses in the BNST following morphine withdrawal, and alterations in BNST inhibitory signaling may contribute to the expression of behaviors following opioid withdrawal.<\/jats:p>","DOI":"10.1111\/adb.12748","type":"journal-article","created":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T08:25:22Z","timestamp":1554798322000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Inhibitory transmission in the bed nucleus of the stria terminalis in male and female mice following morphine withdrawal"],"prefix":"10.1111","volume":"25","author":[{"given":"Brennon R.","family":"Luster","sequence":"first","affiliation":[{"name":"Bowles Center for Alcohol Studies UNC Chapel Hill School of Medicine  Chapel Hill NC USA"},{"name":"Department of Psychiatry UNC Chapel Hill School of Medicine  Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth S.","family":"Cogan","sequence":"additional","affiliation":[{"name":"Bowles Center for Alcohol Studies UNC Chapel Hill School of Medicine  Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl T.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Bowles Center for Alcohol Studies UNC Chapel Hill School of Medicine  Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipanwita","family":"Pati","sequence":"additional","affiliation":[{"name":"Bowles Center for Alcohol Studies UNC Chapel Hill School of Medicine  Chapel Hill NC USA"},{"name":"Department of Pharmacology UNC Chapel Hill School of Medicine  Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie M.","family":"Pina","sequence":"additional","affiliation":[{"name":"Bowles Center for Alcohol Studies UNC Chapel Hill School of Medicine  Chapel Hill NC USA"},{"name":"Department of Pharmacology UNC Chapel Hill School of Medicine  Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kedar","family":"Dange","sequence":"additional","affiliation":[{"name":"Bowles Center for Alcohol Studies UNC Chapel Hill School of Medicine  Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4717-5698","authenticated-orcid":false,"given":"Zo\u00e9 A.","family":"McElligott","sequence":"additional","affiliation":[{"name":"Bowles Center for Alcohol Studies UNC Chapel Hill School of Medicine  Chapel Hill NC USA"},{"name":"Department of Psychiatry UNC Chapel Hill School of Medicine  Chapel Hill NC USA"},{"name":"Department of Pharmacology UNC Chapel Hill School of Medicine  Chapel Hill NC 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