{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:23:37Z","timestamp":1787502217101,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T00:00:00Z","timestamp":1555977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["G0800268"],"award-info":[{"award-number":["G0800268"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014660","name":"Society for the Study of Addiction","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014660","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000374","name":"British Medical Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Understanding genetic factors that contribute to cannabis use disorder (CUD) is important, but to date, findings have been equivocal. Single\u2010nucleotide polymorphisms (SNPs) in the cannabinoid receptor 1 gene (CNR1; rs1049353 and rs806378) and fatty acid amide hydrolase (FAAH) gene (rs324420) have been implicated in CUD. Their relationship to addiction endophenotypes such as cannabis\u2010related state satiety, the salience of appetitive cues, and craving after acute cannabinoid administration has not been investigated. Forty\u2010eight cannabis users participated in a double\u2010blind, placebo\u2010controlled, four\u2010way crossover experiment where they were administered treatments in a randomized order via vaporization: placebo, \u0394\n                    <jats:sup>9<\/jats:sup>\n                    \u2010tetrahydrocannabinol (THC) (8\u00a0mg), THC\u00a0+\u00a0cannabidiol (THC\u00a0+\u00a0CBD) (8\u00a0+\u00a016\u00a0mg), and CBD (16\u00a0mg). Cannabis\u2010related state satiety, appetitive cue salience (cannabis and food), and cannabis craving were assessed each day. Participants were genotyped for rs1049353, rs806378, and rs324420. Results indicated that CNR1 rs1049353 GG carriers showed increased state satiety after THC\/THC\u00a0+\u00a0CBD administration in comparison with placebo and reduced the salience of appetitive cues after THC in comparison with CBD administration; A carriers did not vary on either of these measures indicative of a vulnerability to CUD. CNR1 rs806378 CC carriers showed greater salience to appetitive cues in comparison with T carriers, but there was no evidence for changes in state satiety. FAAH rs324420 A carriers showed greater bias to appetitive cues after THC, in comparison with CC carriers. FAAH CC carriers showed reduced bias after THC in comparison with CBD. No SNPs modulated craving. These findings identify candidate neurocognitive mechanisms through which endocannabinoid system genetics may influence vulnerability to CUD.\n                  <\/jats:p>","DOI":"10.1111\/adb.12762","type":"journal-article","created":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T19:24:17Z","timestamp":1556047457000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Acute effects of cannabinoids on addiction endophenotypes are moderated by genes encoding the CB1 receptor and FAAH enzyme"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1692-7401","authenticated-orcid":false,"given":"Chandni","family":"Hindocha","sequence":"first","affiliation":[{"name":"Clinical Psychopharmacology Unit, Research Department of Clinical, Educational and Health Psychology University College London  London UK"},{"name":"Translational Psychiatry Research Group, Research Department of Mental Health Neuroscience, Division of Psychiatry, Faculty of Brain Sciences University College London  London UK"},{"name":"NIHR University College London Hospitals Biomedical Research Centre University College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom P.","family":"Freeman","sequence":"additional","affiliation":[{"name":"Clinical Psychopharmacology Unit, Research Department of Clinical, Educational and Health Psychology University College London  London UK"},{"name":"Translational Psychiatry Research Group, Research Department of Mental Health Neuroscience, Division of Psychiatry, Faculty of Brain Sciences University College London  London UK"},{"name":"Addiction and Mental Health Group (AIM), Department of Psychology University of Bath  Bath UK"},{"name":"National Addiction Centre, Institute of Psychiatry, Psychology &amp; Neuroscience King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grainne","family":"Schafer","sequence":"additional","affiliation":[{"name":"Clinical Psychopharmacology Unit, Research Department of Clinical, Educational and Health Psychology University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea","family":"Gardner","sequence":"additional","affiliation":[{"name":"Clinical Psychopharmacology Unit, Research Department of Clinical, Educational and Health Psychology University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.P.","family":"Bloomfield","sequence":"additional","affiliation":[{"name":"Clinical Psychopharmacology Unit, Research Department of Clinical, Educational and Health Psychology University College London  London UK"},{"name":"Translational Psychiatry Research Group, Research Department of Mental Health Neuroscience, Division of Psychiatry, Faculty of Brain Sciences University College London  London UK"},{"name":"NIHR University College London Hospitals Biomedical Research Centre University College Hospital  London UK"},{"name":"Division of Psychiatry University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvira","family":"Bramon","sequence":"additional","affiliation":[{"name":"Division of Psychiatry University College London  London UK"},{"name":"Institute of Psychiatry, Psychology &amp; Neuroscience King's College London  London UK"},{"name":"Institute of Cognitive Neuroscience University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia J.A.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Clinical Psychopharmacology Unit, Research Department of Clinical, Educational and Health Psychology University College London  London UK"},{"name":"Psychopharmacology and Addiction Research Centre University of Exeter  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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